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Medicines > generic : 25C-NBOMe or Codeine or Ropinirole

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generic: (Click arrow to add another value)
brand:
None (2) · (multiple, generic dominant) (1) · Requip (IR), Requip XL (extended-release) (1)
classes:
Analgesic (2) · Classic Psychedelic (1) · Opioid (2) · Phenethylamine (1) · Prodrug (1) · Research material (1) · [[:Category:Antiparkinsonians|Antiparkinsonian]] (1) · [[:Category:Dopamine agonists|Dopamine D2/D3 receptor agonist (non-ergot)]] (1)
mechanism:
None (1) · Mu-opioid receptor agonist; prodrug (metabolized to morphine) (1) · Potent 5-HT2A agonist (1) · Prodrug; converted to [[Morphine|morphine]] by [[Enzyme:CYP2D6|CYP2D6]] for analgesic action. (1)
uses:
None (2) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-00000013-QINU`"', '"`UNIQ--vote-00000014-QINU`"' (1)
starting dose:
None (2) · Adult: 15–60 mg every 4 hours as needed. (1) · Parkinson disease: 0.25 mg PO TID, titrate weekly. Restless legs syndrome: 0.25 mg PO 1-3 hours before bedtime, titrate to 4 mg/day if needed (1)
preparations:
None (2) · IR tablets 0.25, 0.5, 1, 2, 3, 4, 5 mg; XL tablets 2, 4, 6, 8, 12 mg (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (2) · 24 mg/day (Parkinson disease); 4 mg/day (restless legs syndrome) (1) · 360 mg/day (1)
routes:
None (2) · Oral (1) · PO (only formulation marketed in the US). (1)
onset:
None (2) · 30–60 min (PO) (1) · Motor improvement over days at therapeutic dose (1)
duration:
None (2) · 4–6 hours (1) · TID dosing (IR); once-daily (XL) (1)
halflife:
None (2) · 2.5–3 hours (1) · ~6 hours'"`UNIQ--ref-00000015-QINU`"' (1)
bioavailability:
None (2) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1) · ~55% (oral)'"`UNIQ--ref-00000016-QINU`"' (1)
pregnancy:
None (2) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1) · Limited human data.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (2) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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