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Drilldown: Medicines

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Medicines > generic : 25C-NBOMe or Timolol (maleate)

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generic: (Click arrow to add another value)
brand:
None (1) · Timoptic (ophthalmic), Timoptic-XE (gel-forming once-daily), Istalol (once-daily 0.5%), Betimol; Blocadren (oral, discontinued in many markets); combination eye drops Combigan (with brimonidine), Cosopt (with dorzolamide) (1)
classes:
Classic Psychedelic (1) · Phenethylamine (1) · Research material (1) · [[:Category:Antiglaucoma medicines|Antiglaucoma medicine]] (1) · [[:Category:Antihypertensives|Antihypertensive]] (1) · [[:Category:Beta blockers|Beta blocker (non-selective)]] (1) · [[:Category:Migraine prophylactics|Migraine prophylactic]] (1)
mechanism:
None (1) · Potent 5-HT2A agonist (1)
uses:
None (1) · '"`UNIQ--vote-00000017-QINU`"', '"`UNIQ--vote-00000018-QINU`"', '"`UNIQ--vote-00000019-QINU`"', '"`UNIQ--vote-0000001A-QINU`"' (1)
starting dose:
None (1) · Ophthalmic: 1 drop 0.5% in affected eye(s) BID (or once daily for XE / Istalol). Oral hypertension: 10 mg PO BID, titrate to 60 mg/day. Migraine prophylaxis: 10 mg BID, titrate to 30 mg/day (1)
preparations:
None (1) · Tablets 5, 10, 20 mg; ophthalmic solution 0.25%, 0.5%; ophthalmic gel-forming solution 0.25%, 0.5% (Timoptic-XE) (1)
fda max:
None (1) · 60 mg/day (oral, hypertension); 0.5% BID (ophthalmic) (1)
routes:
None (1) · ophthalmic (1) · Oral (1)
onset:
None (1) · BP effect within hours (oral); IOP reduction within 30 minutes, full effect 1-2 weeks (ophthalmic) (1)
duration:
None (1) · 12 hours (oral BID); 24 hours (Timoptic-XE) (1)
halflife:
None (1) · ~4 hours (oral)'"`UNIQ--ref-0000001B-QINU`"' (1)
bioavailability:
None (1) · ~50% (oral); systemic absorption from ophthalmic application is clinically meaningful via nasolacrimal drainage'"`UNIQ--ref-0000001C-QINU`"' (1)
pregnancy:
None (1) · Limited human data; β-blocker class effects include fetal growth restriction and neonatal bradycardia/hypoglycemia.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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