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Medicines > generic : 25I-NBOH or Alprazolam or Codeine

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generic: (Click arrow to add another value)
brand:
None (2) · (multiple, generic dominant) (1) · Xanax (1)
classes:
Analgesic (2) · Anxiolytic (1) · Benzodiazepine (1) · Classic Psychedelic (1) · Opioid (2) · Phenethylamine (1) · Prodrug (1) · Research material (1) · Triazolobenzodiazepine (1)
mechanism:
GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1) · Mu-opioid receptor agonist; prodrug (metabolized to morphine) (1) · Potent 5-HT2A agonist (1) · Prodrug; converted to [[Morphine|morphine]] by [[Enzyme:CYP2D6|CYP2D6]] for analgesic action. (1)
uses:
None (2) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1)
starting dose:
None (2) · 0.25 mg (1) · Adult: 15–60 mg every 4 hours as needed. (1)
preparations:
None (2) · 0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (2) · 10 mg/d (1) · 360 mg/day (1)
routes:
None (2) · Oral (1) · PO (only formulation marketed in the US). (1)
onset:
None (2) · 30-60 min (immediate-release); 1-2 h (extended-release) (1) · 30–60 min (PO) (1)
duration:
None (2) · 4–6 hours (1) · 6 h (immediate-release); ~11 h (extended-release) (1)
halflife:
None (2) · 11-13 h (immediate-release); 11-16 h (extended-release) (1) · 2.5–3 hours (1)
bioavailability:
None (2) · 80-90% oral (1) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1)
pregnancy:
None (2) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1) · Category D'"`UNIQ--ref-0000006C-QINU`"' (1)
legal:
None (2) · Schedule IV (US) (1) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1)

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