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Medicines > generic : 25I-NBOMe or 25N-NBOMe or Azelastine

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generic: (Click arrow to add another value)
brand:
None (2) · Astelin, Astepro (intranasal); Optivar (ophthalmic); with fluticasone as Dymista (1)
classes:
Classic Psychedelic (2) · Phenethylamine (2) · Research material (2) · [[:Category:H1_receptor_antagonists|Histamine H1 receptor antagonist]] (1) · [[:Category:Intranasal_antihistamines|Intranasal antihistamine]] (1) · [[:Category:Mast_cell_stabilizers|Mast cell stabilizer]] (1)
mechanism:
5-HT2A agonist (1) · Extremely potent 5-HT2A agonist; vasoconstrictor (1) · '"`UNIQ--vote-000013B1-QINU`"' Topical application minimizes systemic antihistaminic burden; the characteristic bitter taste with nasal use (drainage to oropharynx) is the main tolerability issue'"`UNIQ--ref-000013B2-QINU`"'. (1)
uses:
None (2) · '"`UNIQ--vote-000013B3-QINU`"', '"`UNIQ--vote-000013B4-QINU`"', '"`UNIQ--vote-000013B5-QINU`"' (1)
starting dose:
None (2) · Intranasal 0.1% or 0.15%: 1-2 sprays/nostril BID; ophthalmic 0.05%: 1 drop in each eye BID (1)
preparations:
None (2) · 0.1%, 0.15% intranasal spray; 0.05% ophthalmic solution; combination Dymista (azelastine 0.137 mg + fluticasone 50 mcg/spray) (1)
fda max:
None (2) · 2 sprays/nostril BID (1)
routes:
None (2) · Intranasal (1) · topical ophthalmic (1)
onset:
None (2) · 15 minutes (1)
duration:
None (2) · 12 hours (1)
halflife:
None (2) · ~22 hours; longer 54 hours (desmethylazelastine, active metabolite)'"`UNIQ--ref-000013B6-QINU`"' (1)
bioavailability:
None (2) · Intranasal ~40% systemic; ophthalmic minimal'"`UNIQ--ref-000013B7-QINU`"' (1)
pregnancy:
None (2) · Limited data; second-line to intranasal corticosteroids or PO loratadine/cetirizine.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (2) · OTC (Astepro 0.15%) and [[USLegal:Prescription only|Rx-only]] (other intranasal, ophthalmic, Dymista) in US (1)

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