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Medicines > generic : 25I-NBOMe or Codeine or Doxazosin

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generic: (Click arrow to add another value)
brand:
None (2) · (multiple, generic dominant) (1) · Cardura, Cardura XL (1)
classes:
Analgesic (2) · Classic Psychedelic (1) · Opioid (2) · Phenethylamine (1) · Prodrug (1) · Research material (1) · [[:Category:Alpha-1_blockers|Alpha-1 adrenergic blocker (non-selective)]] (1) · [[:Category:Antihypertensives|Antihypertensive]] (1) · [[:Category:BPH_treatments|Benign prostatic hyperplasia treatment]] (1)
mechanism:
None (1) · Extremely potent 5-HT2A agonist; vasoconstrictor (1) · Mu-opioid receptor agonist; prodrug (metabolized to morphine) (1) · Prodrug; converted to [[Morphine|morphine]] by [[Enzyme:CYP2D6|CYP2D6]] for analgesic action. (1)
uses:
None (2) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-00000AAD-QINU`"', '"`UNIQ--vote-00000AAE-QINU`"', '"`UNIQ--vote-00000AAF-QINU`"' (1)
starting dose:
None (2) · Adult: 15–60 mg every 4 hours as needed. (1) · IR 1 mg PO at bedtime, titrate weekly; XL 4-8 mg PO daily (1)
preparations:
None (2) · 1, 2, 4, 8 mg IR tablets; 4, 8 mg XL tablets (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (2) · 16 mg/d (IR); 8 mg/d (XL) (1) · 360 mg/day (1)
routes:
None (2) · Oral (1) · PO (only formulation marketed in the US). (1)
onset:
None (2) · 30–60 min (PO) (1) · BP and symptomatic LUTS improvement within 1-2 weeks (1)
duration:
None (2) · 24 hours (1) · 4–6 hours (1)
halflife:
None (2) · 2.5–3 hours (1) · ~22 hours'"`UNIQ--ref-00000AB0-QINU`"' (1)
bioavailability:
None (2) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1) · ~65% (oral)'"`UNIQ--ref-00000AB1-QINU`"' (1)
pregnancy:
None (2) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1) · Limited data; rarely indicated in pregnancy.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (2) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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