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Drilldown: Medicines

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Medicines > generic : 25I-NBOMe or Codeine or Evolocumab

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generic: (Click arrow to add another value)
brand:
None (2) · (multiple, generic dominant) (1) · Repatha (1)
classes:
Analgesic (2) · Classic Psychedelic (1) · Opioid (2) · Phenethylamine (1) · Prodrug (1) · Research material (1) · [[:Category:Biologics|Biologic]] (1) · [[:Category:Lipid-lowering_agents|Lipid-lowering agent]] (1) · [[:Category:Monoclonal_antibodies|Monoclonal antibody (fully human IgG2)]] (1) · [[:Category:PCSK9_inhibitors|PCSK9 inhibitor]] (1)
mechanism:
None (1) · Extremely potent 5-HT2A agonist; vasoconstrictor (1) · Mu-opioid receptor agonist; prodrug (metabolized to morphine) (1) · Prodrug; converted to [[Morphine|morphine]] by [[Enzyme:CYP2D6|CYP2D6]] for analgesic action. (1)
uses:
None (2) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-0000147C-QINU`"', '"`UNIQ--vote-0000147D-QINU`"', '"`UNIQ--vote-0000147E-QINU`"' (1)
starting dose:
None (2) · 140 mg SC every 2 weeks OR 420 mg SC monthly (3 consecutive injections 5 minutes apart due to volume) (1) · Adult: 15–60 mg every 4 hours as needed. (1)
preparations:
None (2) · 140 mg/mL single-use prefilled syringe and SureClick autoinjector; Pushtronex 420 mg/3.5 mL on-body infusor (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (2) · 360 mg/day (1) · 420 mg/month (1)
routes:
None (2) · PO (only formulation marketed in the US). (1) · Subcutaneous (1)
onset:
None (2) · 30–60 min (PO) (1) · LDL reduction ~50-60% from baseline at 1-2 weeks (1)
duration:
None (2) · 2-4 weeks per dose (1) · 4–6 hours (1)
halflife:
None (2) · 2.5–3 hours (1) · ~11-17 days'"`UNIQ--ref-0000147F-QINU`"' (1)
bioavailability:
None (2) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1) · ~72% from SC depot'"`UNIQ--ref-00001480-QINU`"' (1)
pregnancy:
None (2) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1) · Limited data.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (2) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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