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Medicines > generic : 25I-NBOMe or Linaclotide

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generic: (Click arrow to add another value)
brand:
None (1) · Linzess (1)
classes:
Classic Psychedelic (1) · Phenethylamine (1) · Research material (1) · [[:Category:Guanylate_cyclase_C_agonists|Guanylate cyclase-C agonist]] (1) · [[:Category:IBS_treatments|IBS-C treatment]] (1)
mechanism:
Extremely potent 5-HT2A agonist; vasoconstrictor (1) · '"`UNIQ--vote-00001197-QINU`"' Extracellular cGMP separately activates submucosal sensory afferents in a way that reduces visceral pain perception, distinguishing linaclotide from purely osmotic laxatives in IBS-C. Diarrhea is the dose-limiting effect'"`UNIQ--ref-00001198-QINU`"'. (1)
uses:
None (1) · '"`UNIQ--vote-00001199-QINU`"', '"`UNIQ--vote-0000119A-QINU`"', '"`UNIQ--vote-0000119B-QINU`"' (1)
starting dose:
None (1) · 145 mcg PO once daily for chronic idiopathic constipation; 290 mcg daily for IBS-C; pediatric 72 mcg daily (1)
preparations:
None (1) · 72, 145, 290 mcg capsules (1)
fda max:
None (1) · 290 mcg/d (1)
routes:
None (1) · Oral (1)
onset:
None (1) · Bowel movement within 1 week; abdominal pain improvement over weeks (1)
duration:
None (1) · 24 hours (1)
halflife:
None (1) · Not meaningfully described (negligible systemic absorption — the drug acts locally and is degraded in the GI tract)'"`UNIQ--ref-0000119C-QINU`"' (1)
bioavailability:
None (1) · Negligible systemic absorption'"`UNIQ--ref-0000119D-QINU`"' (1)
pregnancy:
None (1) · Limited data; minimal systemic absorption likely renders fetal risk low.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (1) · [[USLegal:Prescription only|Rx-only]] in US. Carries a '''Boxed Warning''' contraindicating use in children <2 years (lethal dehydration in animal studies)'"`UNIQ--ref-0000119E-QINU`"' (1)

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