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Medicines > generic : 2C-B or Codeine or Olmesartan (medoxomil)

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generic: (Click arrow to add another value)
brand:
None (1) · (multiple, generic dominant) (1) · Benicar (1) · Nexus, Eroxan (historical, late-1980s through mid-1990s) (1)
classes:
2C-x series (1) · Analgesic (2) · Opioid (2) · Phenethylamine (1) · Prodrug (1) · Psychedelic (1) · [[:Category:Angiotensin_receptor_blockers|Angiotensin receptor blocker (ARB)]] (1) · [[:Category:Antihypertensives|Antihypertensive]] (1)
mechanism:
None (1) · 5-HT2A partial agonist (1) · Mu-opioid receptor agonist; prodrug (metabolized to morphine) (1) · Prodrug; converted to [[Morphine|morphine]] by [[Enzyme:CYP2D6|CYP2D6]] for analgesic action. (1)
uses:
None (2) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-0000056B-QINU`"' (1)
starting dose:
None (2) · 20 mg PO once daily; titrate to 40 mg/d after 2 weeks if needed (1) · Adult: 15–60 mg every 4 hours as needed. (1)
preparations:
None (2) · 5, 20, 40 mg tablets (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (2) · 360 mg/day (1) · 40 mg/d (1)
routes:
None (1) · insufflated (1) · Oral (2) · PO (only formulation marketed in the US). (1) · PR (1)
onset:
None (1) · 30–60 min (PO) (1) · 45-75 min (oral) (1) · BP effect 1-2 weeks; max at 2-3 weeks (1)
duration:
None (1) · 24 hours (1) · 4-8 h (1) · 4–6 hours (1)
halflife:
None (1) · 2.5–3 hours (1) · Not well characterized (1) · ~13 hours'"`UNIQ--ref-0000056C-QINU`"' (1)
bioavailability:
None (1) · Not well characterized (1) · ~26% (oral; prodrug hydrolyzed by intestinal esterases to active olmesartan; not affected by food)'"`UNIQ--ref-0000056D-QINU`"' (1) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1)
pregnancy:
None (1) · '''Contraindicated in pregnancy''' (all trimesters); fetal renal injury, oligohydramnios, hypocalvaria, hypotension. Stop on detection'"`UNIQ--ref-0000056E-QINU`"' (1) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1) · Not established (1)
legal:
None (1) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1) · [[USLegal:DEA Schedule I|Schedule I]] (United States) (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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