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Medicines > generic : 2C-B or Doxepin (hydrochloride)

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generic: (Click arrow to add another value)
brand:
Nexus, Eroxan (historical, late-1980s through mid-1990s) (1) · Sinequan (oral antidepressant, US brand discontinued), Silenor (low-dose for insomnia), Prudoxin / Zonalon (topical cream) (1)
classes:
2C-x series (1) · Phenethylamine (1) · Psychedelic (1) · [[:Category:Antidepressants|Antidepressant]] (1) · [[:Category:Antihistamines|Antihistamine (potent H1)]] (1) · [[:Category:Sleep aids|Sleep aid (Silenor low-dose)]] (1) · [[:Category:Tricyclic antidepressants|Tricyclic antidepressant (TCA)]] (1)
mechanism:
None (1) · 5-HT2A partial agonist (1)
uses:
None (1) · '"`UNIQ--vote-0000001B-QINU`"', '"`UNIQ--vote-0000001C-QINU`"', '"`UNIQ--vote-0000001D-QINU`"', '"`UNIQ--vote-0000001E-QINU`"', '"`UNIQ--vote-0000001F-QINU`"' (1)
starting dose:
None (1) · Depression: 25-75 mg/day to start, titrate to 75-150 mg/day at bedtime. Insomnia (Silenor): 3 mg PO 30 minutes before bedtime, max 6 mg. Topical (Prudoxin): apply to affected area every 3-4 hours (1)
preparations:
None (1) · Capsules 10, 25, 50, 75, 100, 150 mg; oral concentrate 10 mg/mL; Silenor tablets 3, 6 mg; topical cream 5% (Prudoxin, Zonalon) (1)
fda max:
None (1) · 300 mg/day (depression, hospitalized); 150 mg/day outpatient; 6 mg/day for insomnia (1)
routes:
insufflated (1) · Oral (2) · PR (1) · topical (1)
onset:
45-75 min (oral) (1) · Sleep effect from first dose; antidepressant effect over 1-4 weeks (1)
duration:
24 hours (HS dosing) (1) · 4-8 h (1)
halflife:
Not well characterized (1) · ~15 hours (parent); nordoxepin active metabolite ~30 hours'"`UNIQ--ref-00000020-QINU`"' (1)
bioavailability:
Not well characterized (1) · ~30% (oral)'"`UNIQ--ref-00000021-QINU`"' (1)
pregnancy:
Not established (1) · TCA class signal; limited human data specific to doxepin.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:DEA Schedule I|Schedule I]] (United States) (1) · [[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-00000022-QINU`"' (1)

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