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Medicines > generic : 2C-B or Olanzapine / Fluoxetine

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generic: (Click arrow to add another value)
brand:
Nexus, Eroxan (historical, late-1980s through mid-1990s) (1) · Symbyax (1)
classes:
2C-x series (1) · Phenethylamine (1) · Psychedelic (1) · SSRI)]] (1) · [[:Category:Antidepressants|Antidepressant (fluoxetine (1) · [[:Category:Fixed-dose_combinations|Fixed-dose combination]] (1) · [[:Category:Mood_stabilizers|Mood stabilizer]] (1) · [[:Category:Neuroleptics|Atypical neuroleptic (olanzapine)]] (1)
mechanism:
5-HT2A partial agonist (1) · '"`UNIQ--vote-00001549-QINU`"' Metabolic effects (weight gain, dyslipidemia, glucose dysregulation) dominate the long-term tolerability profile; routine metabolic monitoring is standard'"`UNIQ--ref-0000154A-QINU`"'. (1)
uses:
None (1) · '"`UNIQ--vote-0000154B-QINU`"', '"`UNIQ--vote-0000154C-QINU`"' (1)
starting dose:
None (1) · 6/25 mg PO once daily in the evening; titrate within range 3/25 to 18/75 mg by clinical response and tolerability (1)
preparations:
None (1) · Capsules: 3/25, 6/25, 6/50, 12/25, 12/50 mg olanzapine/fluoxetine (1)
fda max:
None (1) · 18 mg olanzapine / 75 mg fluoxetine per day (1)
routes:
insufflated (1) · Oral (2) · PR (1)
onset:
45-75 min (oral) (1) · Mood improvement at 1-3 weeks; full effect 4-6 weeks (1)
duration:
24 hours (1) · 4-8 h (1)
halflife:
Not well characterized (1) · Olanzapine ~30 hours; fluoxetine 1-4 days (norfluoxetine 7-15 days)'"`UNIQ--ref-0000154D-QINU`"' (1)
bioavailability:
Not well characterized (1) · Olanzapine 60% (oral); fluoxetine high (oral)'"`UNIQ--ref-0000154E-QINU`"' (1)
pregnancy:
Limited data; fluoxetine has reassuring data but olanzapine carries metabolic-syndrome and gestational diabetes signals.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Not established (1)
legal:
[[USLegal:DEA Schedule I|Schedule I]] (United States) (1) · [[USLegal:Prescription only|Rx-only]] in US. Carries the '''antidepressant Boxed Warning''' for suicidality in children/adolescents/young adults and the atypical-neuroleptic '''Boxed Warning''' for increased mortality in elderly dementia patients'"`UNIQ--ref-0000154F-QINU`"' (1)

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