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Medicines > generic : 2C-B or Quetiapine

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generic: (Click arrow to add another value)
brand:
Nexus, Eroxan (historical, late-1980s through mid-1990s) (1) · Seroquel (1)
classes:
2C-x series (1) · Phenethylamine (1) · Psychedelic (1) · [[:Category:Dibenzothiazepines|Dibenzothiazepine]] (1) · [[:Category:Neuroleptics|Neuroleptic]] (1) · [[:Category:Second-generation neuroleptics|Second-generation (atypical) neuroleptic]] (1) · [[:Category:Serotonin-dopamine antagonists|Serotonin-dopamine antagonist]] (1)
mechanism:
5-HT2A partial agonist (1) · Dopamine D2 and serotonin 5-HT2A receptor antagonist'"`UNIQ--ref-0000008D-QINU`"' '"`UNIQ--vote-0000008E-QINU`"' (1)
uses:
None (1) · '"`UNIQ--vote-0000008F-QINU`"', '"`UNIQ--vote-00000090-QINU`"', '"`UNIQ--vote-00000091-QINU`"', '"`UNIQ--vote-00000092-QINU`"' (1)
starting dose:
None (1) · 25 mg (schizophrenia, immediate-release); 50 mg (bipolar mania, immediate-release); 50 mg (Seroquel XR, schizophrenia or bipolar) (1)
preparations:
None (1) · 25 mg, 50 mg, 100 mg, 200 mg, 300 mg, 400 mg immediate-release tablets; 50 mg, 150 mg, 200 mg, 300 mg, 400 mg extended-release tablets (Seroquel XR) (1)
fda max:
None (1) · 800 mg/day (1)
routes:
insufflated (1) · Oral (2) · PR (1)
onset:
30-60 min (sedation); days to weeks (neuroleptic effect) (1) · 45-75 min (oral) (1)
duration:
4-8 h (1) · 6-8 h (immediate-release); 24 h (extended-release) (1)
halflife:
Not well characterized (1) · ~6 h (parent compound, immediate-release); ~9-12 h (active metabolite N-desalkylquetiapine, also called norquetiapine) (1)
bioavailability:
Not well characterized (1) · Tablet ~100% relative to oral solution; extensive first-pass metabolism (1)
pregnancy:
Not established (1) · Pregnancy categories were retired by FDA in 2015. Quetiapine has reassuring active-comparator cohort data without consistent teratogenic signal; among the preferred neuroleptics when treatment is clinically necessary in pregnancy. See pregnancy_details for the full citation set. (1)
legal:
[[USLegal:DEA Schedule I|Schedule I]] (United States) (1) · [[USLegal:Prescription only|Prescription only]]; not a controlled substance (1)

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