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Medicines > generic : Chlorthalidone or Codeine

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generic: (Click arrow to add another value)
brand:
None (1) · (multiple, generic dominant) (1) · Thalitone; mostly prescribed generically (1)
classes:
Analgesic (2) · Opioid (2) · Prodrug (1) · [[:Category:Antihypertensives|Antihypertensive]] (1) · [[:Category:Thiazide-like_diuretics|Thiazide-like diuretic]] (1)
mechanism:
None (1) · Mu-opioid receptor agonist; prodrug (metabolized to morphine) (1) · Prodrug; converted to [[Morphine|morphine]] by [[Enzyme:CYP2D6|CYP2D6]] for analgesic action. (1)
uses:
None (1) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-00000780-QINU`"', '"`UNIQ--vote-00000781-QINU`"', '"`UNIQ--vote-00000782-QINU`"' (1)
starting dose:
None (1) · 12.5-25 mg PO once daily; titrate to 50 mg (1) · Adult: 15–60 mg every 4 hours as needed. (1)
preparations:
None (1) · 15 mg, 25 mg, 50 mg tablets (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (1) · 100 mg/d (rarely used) (1) · 360 mg/day (1)
routes:
None (1) · Oral (1) · PO (only formulation marketed in the US). (1)
onset:
None (1) · 30–60 min (PO) (1) · Diuresis at 2-3 hours; BP effect over weeks (1)
duration:
None (1) · 48-72 hours per dose (much longer than hydrochlorothiazide) (1) · 4–6 hours (1)
halflife:
None (1) · 2.5–3 hours (1) · 40-60 hours (notable for the thiazide class)'"`UNIQ--ref-00000783-QINU`"' (1)
bioavailability:
None (1) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1) · ~65% (oral)'"`UNIQ--ref-00000784-QINU`"' (1)
pregnancy:
None (1) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1) · Avoided where possible; same class concerns as HCTZ.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (1) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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