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Medicines > generic : Codeine or Nabumetone & onset: Analgesia within hours; anti-inflammatory effect over days

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generic: (Click arrow to add another value)
brand:
Relafen (1)
classes:
[[:Category:Acetic_acid_derivatives|Acetic acid derivative]] (1) · [[:Category:NSAIDs|Non-steroidal anti-inflammatory drug (NSAID)]] (1)
mechanism:
'"`UNIQ--vote-000011F4-QINU`"' Like all NSAIDs, raises CV thrombotic risk modestly (FDA 2014/2015 advisory) and produces GI, renal, hypertensive, and platelet-inhibitory effects characteristic of the class'"`UNIQ--ref-000011F5-QINU`"'. (1)
uses:
'"`UNIQ--vote-000011F6-QINU`"', '"`UNIQ--vote-000011F7-QINU`"', '"`UNIQ--vote-000011F8-QINU`"' (1)
starting dose:
1000 mg PO once daily; 500-2000 mg/d in single or divided doses (1)
preparations:
500, 750 mg tablets (1)
fda max:
2000 mg/d (1)
routes:
Oral (1)
onset: (Click arrow to add another value)
duration:
24 hours (1)
halflife:
~24 hours (6-methoxy-2-naphthylacetic acid, the active metabolite)'"`UNIQ--ref-000011F9-QINU`"' (1)
bioavailability:
~38% (oral; non-acidic prodrug improves GI tolerability over many other NSAIDs)'"`UNIQ--ref-000011FA-QINU`"' (1)
pregnancy:
Avoid after 20 weeks (NSAID-class FDA 2020 advisory on fetal renal injury and oligohydramnios with second/third-trimester use).<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US. Carries the NSAID-class '''Boxed Warning''' for cardiovascular thrombotic events and serious GI bleeding'"`UNIQ--ref-000011FB-QINU`"' (1)

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