Jump to content

Drilldown: Medicines

Choose a table:


Medicines > generic : Codeine or Pravastatin

Use the filters below to narrow your results.

generic: (Click arrow to add another value)
brand:
None (1) · (multiple, generic dominant) (1) · Pravachol (1)
classes:
Analgesic (2) · Opioid (2) · Prodrug (1) · [[:Category:Lipid-lowering_agents|Lipid-lowering agent]] (1) · [[:Category:Statins|Statin]] (1)
mechanism:
Mu-opioid receptor agonist; prodrug (metabolized to morphine) (1) · Prodrug; converted to [[Morphine|morphine]] by [[Enzyme:CYP2D6|CYP2D6]] for analgesic action. (1) · '"`UNIQ--vote-000003D1-QINU`"' SLCO1B1 polymorphism affects exposure but is most clinically actionable for simvastatin'"`UNIQ--ref-000003D2-QINU`"'. (1)
uses:
None (1) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-000003D3-QINU`"', '"`UNIQ--vote-000003D4-QINU`"' (1)
starting dose:
None (1) · 40 mg PO once daily (10-20 mg in elderly, hepatic impairment, or strong drug interactions) (1) · Adult: 15–60 mg every 4 hours as needed. (1)
preparations:
None (1) · 10 mg, 20 mg, 40 mg, 80 mg tablets (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (1) · 360 mg/day (1) · 80 mg/d (1)
routes:
None (1) · Oral (1) · PO (only formulation marketed in the US). (1)
onset:
None (1) · 30–60 min (PO) (1) · LDL lowering at 2 weeks, max by 4 weeks (1)
duration:
None (1) · 24 hours (1) · 4–6 hours (1)
halflife:
None (1) · 2.5–3 hours (1) · ~2-3 hours (parent); pharmacodynamic effect 24 hours via target turnover'"`UNIQ--ref-000003D5-QINU`"' (1)
bioavailability:
None (1) · ~17% (oral; food slightly reduces absorption)'"`UNIQ--ref-000003D6-QINU`"' (1) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1)
pregnancy:
None (1) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1) · Previously Category X; FDA removed the blanket statin contraindication in pregnancy in 2021.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (1) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

Showing below up to 3 results in range #1 to #3.

View (previous 250 | next 250) (20 | 50 | 100 | 250 | 500)


View (previous 250 | next 250) (20 | 50 | 100 | 250 | 500)

Retrieved from "https://pharmacopedia.wiki/p/Special:Drilldown/Medicines"