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Medicines (732)

Medicines > generic

: Fluorouracil (5-FU)

or None

& routes: Intranasal (under direct medical supervision)

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Spravato (1)

dissociative (1) · NMDA receptor antagonist (uncompetitive) (1)

None (1)

Treatment-resistant depression (TRD) in adults, as adjunct to oral antidepressant (FDA-approved March 2019). Depressive symptoms in adults with MDD with acute suicidal ideation or behavior (FDA-approved Aug 2020). (1)

Induction (TRD): 56 mg intranasal twice weekly × 4 weeks. Maintenance: 56-84 mg once weekly × 4 weeks, then 56-84 mg every 1-2 weeks. For acute suicidality: 84 mg twice weekly × 4 weeks. Administered under medical supervision in REMS-certified site. (1)

28 mg/device (each dose uses 2 devices) (1)

84 mg per session (1)

Within hours of first administration (1)

Acute effect ~24 hours; cumulative effect builds with repeated dosing (1)

~7-12 hours (1)

~48% intranasal (1)

Avoid; may cause fetal harm (1)

Rx, Schedule III (US). REMS program required. (1)

Showing below up to 1 result in range #1 to #1.

E

Esketamine

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