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Medicines > generic : Insulin aspart or None & routes: Subcutaneous

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generic: (Click arrow to add another value)
brand:
Aimovig (1) · Ajovy (1) · Emgality (1) · NovoLog, Fiasp (ultra-rapid), Trurapi (1)
classes:
Anti-CGRP ligand monoclonal antibody (2) · Anti-CGRP receptor monoclonal antibody (1) · [[:Category:Insulins|Insulin]] (1) · [[:Category:Mealtime_insulins|Mealtime (bolus) insulin]] (1) · [[:Category:Rapid-acting_insulins|Rapid-acting insulin analog]] (1)
mechanism:
None (1) · Humanized IgG2 monoclonal antibody binding both isoforms of CGRP peptide (1) · Humanized IgG2 monoclonal antibody binding the CGRP receptor (not the peptide); blocks CGRP-mediated vasodilation and nociceptive signaling (1) · Humanized IgG4 monoclonal antibody binding CGRP peptide; prevents CGRP from activating its receptor (1)
uses:
Preventive treatment of migraine in adults (episodic and chronic) (2) · Preventive treatment of migraine in adults; episodic cluster headache (1) · '"`UNIQ--vote-000005EF-QINU`"', '"`UNIQ--vote-000005F0-QINU`"', '"`UNIQ--vote-000005F1-QINU`"' (1)
starting dose:
225 mg SC monthly, or 675 mg SC every 3 months (quarterly) (1) · 70 mg SC monthly; may increase to 140 mg monthly (1) · Migraine: 240 mg SC loading dose, then 120 mg SC monthly. Cluster: 300 mg SC at onset of cluster period, then monthly during cluster. (1) · SC 4-6 units (or 1 unit per 10-15 g carbs) at meals; titrate to postprandial glucose (1)
preparations:
100 U/mL (NovoLog, Fiasp) vials, pens, cartridges (1) · 120 mg/mL prefilled syringe or autoinjector (1) · 225 mg/1.5 mL prefilled syringe or autoinjector (1) · 70 mg/mL or 140 mg/mL prefilled autoinjector (1)
fda max:
140 mg/month (1) · 240 mg loading + 120 mg/month for migraine; 300 mg/month for cluster (1) · 675 mg/quarter (1) · Titrated to glucose; no fixed maximum (1)
routes: (Click arrow to add another value)
onset:
Onset of preventive effect over weeks; some patients respond after first dose (1) · Over weeks (2) · SC: 5-15 minutes (Fiasp 2.5 minutes earlier on average) (1)
duration:
3-5 hours (1) · Monthly dosing (2) · Monthly or quarterly dosing (1)
halflife:
~27 days (1) · ~28 days (1) · ~31 days (1) · ~80 minutes SC'"`UNIQ--ref-000005F2-QINU`"' (1)
bioavailability:
Not formally established (1) · Not formally established (high SC) (1) · ~100% from subcutaneous depot (1) · ~82% SC (1)
pregnancy:
Insulin is the preferred glucose-lowering therapy in pregnancy; aspart is widely used.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Limited data; avoid (3)
legal:
Rx (3) · [[USLegal:Prescription only|Rx-only]] in US (1)

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