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Medicines > generic : Sodium bicarbonate or None & halflife: Not applicable (electrolyte and buffer)

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generic: (Click arrow to add another value)
brand:
Neut, many generic; OTC oral: Alka-Seltzer (with aspirin/citric acid), baking soda (1)
classes:
[[:Category:Antacids|Antacid]] (1) · [[:Category:Electrolyte_replacements|Electrolyte replacement]] (1)
mechanism:
'"`UNIQ--vote-00000016-QINU`"' Bicarbonate is not benign: high-volume use produces hypernatremia, metabolic alkalosis, hypokalemia, and (in arrest) paradoxical intracellular acidosis'"`UNIQ--ref-00000017-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000018-QINU`"', '"`UNIQ--vote-00000019-QINU`"', '"`UNIQ--vote-0000001A-QINU`"', '"`UNIQ--vote-0000001B-QINU`"', '"`UNIQ--vote-0000001C-QINU`"' (1)
starting dose:
IV: 1 mEq/kg bolus in arrest indication, then titrated to ABG and clinical status; PO: 325-2000 mg up to QID as antacid (1)
preparations:
4.2%, 7.5%, 8.4% IV (1 mEq/mL at 8.4%); 325, 650 mg oral tablets; bulk powder (1)
fda max:
No fixed maximum; titrated to pH and bicarbonate level; chronic high oral doses cause metabolic alkalosis and volume overload (1)
routes:
IV (1) · oral (1)
onset:
Immediate (IV); within minutes (oral antacid) (1)
duration:
IV: hours, dependent on ongoing acid load; oral antacid: ~30 minutes (1)
halflife: (Click arrow to add another value)
bioavailability:
100% (IV); rapidly neutralized by gastric acid (oral) (1)
pregnancy:
Routine antacid and acidosis correction acceptable (1)
legal:
[[USLegal:Prescription only|Rx-only]] for IV formulations; OTC for oral (1)

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