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Medicines > generic : Tramadol / Acetaminophen or None & onset: Wake-promoting effect over weeks of titration

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generic: (Click arrow to add another value)
brand:
Wakix (1)
classes:
Histamine H3 receptor inverse agonist / antagonist (1) · wake-promoting agent (1)
mechanism:
None (1)
uses:
Excessive daytime sleepiness or cataplexy in adults with narcolepsy (FDA-approved August 2019) (1)
starting dose:
Week 1: 8.9 mg PO once daily in the morning. Week 2: 17.8 mg. Week 3+: 35.6 mg (max). Titrate as needed. (1)
preparations:
4.45 mg, 17.8 mg tablets (1)
fda max:
35.6 mg/d (1)
routes:
Oral (1)
onset: (Click arrow to add another value)
duration:
Daily morning dosing (1)
halflife:
~20 hours (1)
bioavailability:
Not formally established; oral once-daily adequate (1)
pregnancy:
Limited data; pitolisant may reduce hormonal contraceptive efficacy (1)
legal:
Rx, '''not a controlled substance''' (unique among wake-promoting agents) (1)

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