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Medicines > generic: Amlodipine & halflife: 30-50 hours'"`UNIQ--ref-00000078-QINU`"'

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generic: (Click arrow to add another value)
brand:
Norvasc, Katerzia (1)
classes:
[[:Category:Antianginals|Antianginal]] (1) · [[:Category:Antihypertensives|Antihypertensive]] (1) · [[:Category:Calcium_channel_blockers|Calcium channel blocker]] (1)
mechanism:
'"`UNIQ--vote-00000073-QINU`"' The long half-life gives smooth, once-daily BP control with low rebound. CYP3A4 substrate; pedal edema is the characteristic, dose-related, non-fluid-overload side effect'"`UNIQ--ref-00000074-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000075-QINU`"', '"`UNIQ--vote-00000076-QINU`"', '"`UNIQ--vote-00000077-QINU`"' (1)
starting dose:
2.5-5 mg PO once daily; titrate to 10 mg/d (1)
preparations:
2.5, 5, 10 mg tablets; 1 mg/mL oral suspension (1)
fda max:
10 mg/d (1)
routes:
Oral (1)
onset:
BP effect within 24 hours; full effect at 1-2 weeks (long half-life) (1)
duration:
24 hours (1)
halflife: (Click arrow to add another value)
bioavailability:
64-90% (oral; not affected by food)'"`UNIQ--ref-00000079-QINU`"' (1)
pregnancy:
Limited data; case series and registries suggest no major teratogenicity but other antihypertensives (labetalol, nifedipine) are typically preferred.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)
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