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Medicines > generic: Cyclobenzaprine & onset : IOP lowering at 3-4 hours; maximum at 8-12 hours or ~1 hour

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generic: (Click arrow to add another value)
brand:
Flexeril (IR; brand discontinued in US, generic widely available), Amrix (ER) (1)
classes:
[[:Category:Skeletal muscle relaxants|Skeletal muscle relaxant (centrally-acting)]] (1) · [[:Category:Tricyclic-related compounds|Tricyclic-related compound]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000017-QINU`"', '"`UNIQ--vote-00000018-QINU`"', '"`UNIQ--vote-00000019-QINU`"' (1)
starting dose:
IR 5 mg PO TID; titrate to 10 mg TID if needed. Amrix ER 15 mg PO once daily. Off-label insomnia / fibromyalgia: 5-10 mg PO at bedtime (1)
preparations:
IR tablets 5, 7.5, 10 mg; Amrix ER capsules 15, 30 mg (1)
fda max:
30 mg/day (IR or ER) (1)
routes:
Oral (1)
onset: (Click arrow to add another value)
duration:
12-24 hours (IR); 24 hours (Amrix ER) (1)
halflife:
18 hours (IR); 32-33 hours (ER)'"`UNIQ--ref-0000001A-QINU`"' (1)
bioavailability:
~33-55% (IR); reduced by food'"`UNIQ--ref-0000001B-QINU`"' (1)
pregnancy:
Limited human data.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US. Not a controlled substance, distinguishing it from the carisoprodol alternative for muscle spasm'"`UNIQ--ref-0000001C-QINU`"' (1)

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