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Medicines > generic: Exenatide & pregnancy: Avoid. Discontinue before planned pregnancy.'"`UNIQ--ref-000000EF-QINU`"'

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generic: (Click arrow to add another value)
brand:
Byetta (twice-daily), Bydureon BCise (weekly) (1)
classes:
[[GLP-1 receptor agonist]] · [[Antidiabetic medicines|Antidiabetic]] · First-in-class incretin mimetic (1)
mechanism:
Agonist of the [[GLP-1 receptor]]; exendin-4 derivative from Gila monster venom. (1)
uses:
[[Type 2 diabetes mellitus]] (adjunct, second-line) (1)
starting dose:
Byetta: 5 µg SC twice daily, within 60 min before morning and evening meals'"`UNIQ--ref-000000E3-QINU`"' · Bydureon BCise: 2 mg SC once weekly'"`UNIQ--ref-000000E4-QINU`"' (1)
preparations:
Byetta pre-filled multi-dose pen: 5 µg / 10 µg per dose'"`UNIQ--ref-000000E5-QINU`"' · Bydureon BCise single-dose autoinjector: 2 mg extended-release microsphere suspension'"`UNIQ--ref-000000E6-QINU`"' (1)
fda max:
10 µg twice daily (Byetta)'"`UNIQ--ref-000000E7-QINU`"' · 2 mg once weekly (Bydureon BCise)'"`UNIQ--ref-000000E8-QINU`"' (1)
routes:
Subcutaneous (abdomen (1) · thigh (1) · upper arm)'"`UNIQ--ref-000000E9-QINU`"' (1)
onset:
Glycemic effect within hours (Byetta); weeks (Bydureon, extended-release microsphere)'"`UNIQ--ref-000000EA-QINU`"' (1)
duration:
~10 hours (Byetta)'"`UNIQ--ref-000000EB-QINU`"' · ~7 days steady-state (Bydureon, after ~6–7 weeks of weekly dosing to reach steady state)'"`UNIQ--ref-000000EC-QINU`"' (1)
halflife:
~2.4 hours (Byetta, short, hence the BID schedule)'"`UNIQ--ref-000000ED-QINU`"' · Effective release half-life ~2 weeks (Bydureon)'"`UNIQ--ref-000000EE-QINU`"' (1)
bioavailability:
SC ~65%–75%<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
pregnancy: (Click arrow to add another value)
legal:
Rx-only;'"`UNIQ--ref-000000F0-QINU`"' not a controlled substance (1)
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