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Medicines > generic: Famotidine & halflife: 2.5-3.5 hours; longer in renal impairment'"`UNIQ--ref-0000025B-QINU`"'

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generic: (Click arrow to add another value)
brand:
Pepcid, Pepcid AC, Pepcid Complete (1)
classes:
[[:Category:Antisecretory_agents|Gastric acid suppressant]] (1) · [[:Category:H2_receptor_antagonists|Histamine H2 receptor antagonist]] (1)
mechanism:
'"`UNIQ--vote-00000255-QINU`"' Less potent and shorter-acting than PPIs but with faster on-effect; suitable for on-demand acid suppression. Largely renally cleared; dose-adjust in renal impairment to avoid CNS effects (confusion in elderly)'"`UNIQ--ref-00000256-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000257-QINU`"', '"`UNIQ--vote-00000258-QINU`"', '"`UNIQ--vote-00000259-QINU`"', '"`UNIQ--vote-0000025A-QINU`"' (1)
starting dose:
20 mg PO twice daily, or 40 mg at bedtime (1)
preparations:
10 mg, 20 mg, 40 mg tablets; chewables; 40 mg/5 mL oral suspension; 10 mg/mL IV (1)
fda max:
160 mg/d (Zollinger-Ellison); 80 mg/d for routine indications (1)
routes:
IV (1) · Oral (1)
onset:
1 hour PO; minutes IV (1)
duration:
6-12 hours (1)
halflife: (Click arrow to add another value)
bioavailability:
40-45% (oral; not significantly affected by food)'"`UNIQ--ref-0000025C-QINU`"' (1)
pregnancy:
Generally considered safe; widely used. Cleared in lactation at low levels.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC (10-20 mg) and [[USLegal:Prescription only|Rx-only]] (higher doses) in US (1)
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