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Medicines > generic: Insulin detemir & routes: Subcutaneous & halflife: ~7 hours apparent'"`UNIQ--ref-00001374-QINU`"'

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generic: (Click arrow to add another value)
brand:
Levemir, Levemir FlexTouch (US discontinuation announced 2024) (1)
classes:
[[:Category:Basal_insulins|Basal insulin]] (1) · [[:Category:Insulins|Insulin]] (1) · [[:Category:Long-acting_insulins|Long-acting insulin analog]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00001372-QINU`"', '"`UNIQ--vote-00001373-QINU`"' (1)
starting dose:
~10 units SC at the same time daily, or 0.1-0.2 units/kg/d; titrate by fasting glucose. Frequently dosed BID at moderate-to-high doses (1)
preparations:
100 U/mL FlexTouch pen, vial (1)
fda max:
Titrated to glucose (1)
routes: (Click arrow to add another value)
onset:
1-2 hours (1)
duration:
~12-24 hours (dose-dependent; BID dosing often needed at higher doses) (1)
halflife: (Click arrow to add another value)
bioavailability:
~60% from subcutaneous depot (reduced by reversible albumin binding via the myristic acid side chain that also extends duration)'"`UNIQ--ref-00001375-QINU`"' (1)
pregnancy:
One of the better-studied basal insulin analogs in pregnancy; reassuring data.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)
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