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Medicines > generic: Pioglitazone & onset: HbA1c effect at 12-16 weeks (slower than other classes)

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generic: (Click arrow to add another value)
brand:
Actos (1)
classes:
[[:Category:Antihyperglycemic_agents|Antihyperglycemic agent]] (1) · [[:Category:PPAR_gamma_agonists|PPAR-γ agonist]] (1) · [[:Category:Thiazolidinediones|Thiazolidinedione (TZD)]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000822-QINU`"', '"`UNIQ--vote-00000823-QINU`"' (1)
starting dose:
15-30 mg PO once daily; titrate to 45 mg (1)
preparations:
15, 30, 45 mg tablets (1)
fda max:
45 mg/d (1)
routes:
Oral (1)
onset: (Click arrow to add another value)
duration:
24 hours (1)
halflife:
~3-7 hours (parent); 16-24 hours including active metabolites'"`UNIQ--ref-00000824-QINU`"' (1)
bioavailability:
High (oral; absorption not affected by food)'"`UNIQ--ref-00000825-QINU`"' (1)
pregnancy:
Limited data; switch to insulin where feasible.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US. Carries a '''Boxed Warning''' for heart failure (do not initiate in NYHA III/IV; can precipitate or worsen HF in any patient)'"`UNIQ--ref-00000826-QINU`"' (1)
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