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Drilldown: Medicines

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Medicines > generic: Sildenafil & onset : 30–60 min or IV pulse: hours; PO: hours; intra-articular: days

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generic: (Click arrow to add another value)
brand:
Viagra, Revatio (1)
classes:
PDE5 Inhibitor (1)
mechanism:
Selective inhibitor of phosphodiesterase type 5 (PDE5), preventing cGMP breakdown in vascular smooth muscle. In the corpus cavernosum, potentiates the NO/cGMP cascade triggered by sexual stimulation. (1)
uses:
'"`UNIQ--vote-00000705-QINU`"', '"`UNIQ--vote-00000706-QINU`"' (1)
starting dose:
50 mg ~1 h before sexual activity (ED); 20 mg TID (PAH) (1)
preparations:
25, 50, 100 mg tabs (Viagra); 20 mg tabs and 10 mg/mL oral suspension (Revatio) (1)
fda max:
100 mg/d (ED); 20 mg TID (PAH) (1)
routes:
IV (Revatio) (1) · Oral (1)
onset: (Click arrow to add another value)
duration:
~4 h (1)
halflife:
~4 h (1)
bioavailability:
~40% (1)
pregnancy:
Category B (1)
legal:
Rx-only in US (1)

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