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Medicines > generic: Terbinafine & routes : IV/IM (Buprenex). Oral swallowed: very low bioavailability due to first-pass; not therapeutic. or Topical

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generic: (Click arrow to add another value)
brand:
Lamisil; OTC topical Lamisil AT (1)
classes:
[[:Category:Allylamines|Allylamine]] (1) · [[:Category:Antifungals|Antifungal (allylamine)]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000EAF-QINU`"', '"`UNIQ--vote-00000EB0-QINU`"', '"`UNIQ--vote-00000EB1-QINU`"' (1)
starting dose:
Oral: 250 mg PO once daily × 6 weeks (fingernails) or 12 weeks (toenails); topical: cream BID × 1-2 weeks (1)
preparations:
250 mg tablets; 1% topical cream, gel, spray; granules (pediatric) (1)
fda max:
250 mg/d (1)
routes: (Click arrow to add another value)
onset:
Clinical and mycologic cure follows the full course; nail clearance over months of regrowth (1)
duration:
24 hours (1)
halflife:
~36 hours (terminal much longer due to tissue accumulation in skin/nails)'"`UNIQ--ref-00000EB2-QINU`"' (1)
bioavailability:
~40% (oral; food does not significantly affect)'"`UNIQ--ref-00000EB3-QINU`"' (1)
pregnancy:
Limited data; generally avoided in pregnancy for the cosmetic indication of onychomycosis.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC (topical) and [[USLegal:Prescription only|Rx-only]] (oral) in US (1)

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