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Drilldown: Medicines

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Medicines > generic: None & halflife : ~12 hours or ~7.1 hours

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generic: (Click arrow to add another value)
brand:
Belsomra (1) · Sunosi (1)
classes:
Dual orexin receptor antagonist (DORA) (1) · Norepinephrine-dopamine reuptake inhibitor (NDRI) (1) · the first approved (1) · wake-promoting agent (1)
mechanism:
Competitive antagonist at OX1R and OX2R. First-in-class DORA. Receptor dissociation slower than lemborexant or daridorexant. (1) · Selective dopamine and norepinephrine reuptake inhibitor (DAT and NET inhibition). Unlike amphetamine, does not significantly release monoamines, pure reuptake inhibition. (1)
uses:
Excessive daytime sleepiness in adults with narcolepsy or obstructive sleep apnea (OSA) (1) · Insomnia (sleep onset and/or maintenance) in adults (FDA-approved August 2014). Also studied for insomnia in mild-moderate Alzheimer disease. (1)
starting dose:
10 mg PO 30 min before bedtime (with ≥7 hours of sleep planned) (1) · Narcolepsy: 75 mg PO once daily upon awakening, titrate every 3 days. OSA: 37.5 mg PO once daily, titrate. (1)
preparations:
5 mg, 10 mg, 15 mg, 20 mg tablets (1) · 75 mg, 150 mg tablets (1)
fda max:
150 mg/d (1) · 20 mg/d (1)
routes:
Oral (2)
onset:
~30 min (1) · ~30-60 min (1)
duration:
~7-8 hours (1) · ~9 hours (1)
halflife: (Click arrow to add another value)
bioavailability:
~82% (1) · ~95% (1)
pregnancy:
Limited data; avoid (1) · Limited data; pregnancy exposure registry available (1)
legal:
Rx, Schedule IV (US) (2)

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