Drilldown: Medicines

None · Codeine · 1,4-Butanediol · 1B-LSD · 1cP-LSD · 1P-LSD · 1V-LSD · 2-AI · 2-FA · 2-FDCK · 2-FMA · 25B-NBOH · 25B-NBOMe · 25C-NBOH · 25C-NBOMe · 25I-NBOH · 25I-NBOMe · 25N-NBOMe · 2C-B · 2C-B-FLY

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Ajovy (1) · Emgality (1) · Zurzuvae (1)

Anti-CGRP ligand monoclonal antibody (2) · GABA-A positive allosteric modulator (oral) (1) · Neuroactive steroid (1)

Humanized IgG2 monoclonal antibody binding both isoforms of CGRP peptide (1) · Humanized IgG4 monoclonal antibody binding CGRP peptide; prevents CGRP from activating its receptor (1) · Synthetic neuroactive steroid (an analog of allopregnanolone), bioavailable orally unlike brexanolone. Positive allosteric modulator at GABA-A receptors including extrasynaptic δ-containing subtypes. (1)

Postpartum depression (PPD) in adults (FDA-approved 2023) (1) · Preventive treatment of migraine in adults (episodic and chronic) (1) · Preventive treatment of migraine in adults; episodic cluster headache (1)

225 mg SC monthly, or 675 mg SC every 3 months (quarterly) (1) · 50 mg PO once daily with fatty food in the evening × 14 days (1) · Migraine: 240 mg SC loading dose, then 120 mg SC monthly. Cluster: 300 mg SC at onset of cluster period, then monthly during cluster. (1)

120 mg/mL prefilled syringe or autoinjector (1) · 20 mg, 25 mg, 30 mg capsules (1) · 225 mg/1.5 mL prefilled syringe or autoinjector (1)

240 mg loading + 120 mg/month for migraine; 300 mg/month for cluster (1) · 50 mg/d × 14 d (1) · 675 mg/quarter (1)

Oral (1) · Subcutaneous (2)

None · Hours · 30-60 minutes · 1-2 hours · ~30 min · LDL lowering at 2 weeks, max by 4 weeks · ~1 hour · 15-30 minutes · 15–30 min · 1–2 h · 30–60 min · Antidepressant effect emerges over 1-2 weeks · BP and symptomatic LUTS improvement within 1-2 weeks · BP effect within 1-2 weeks · Clinical improvement within 24-72 hours · Days · Motor improvement over days at therapeutic dose · Over weeks · Postprandial glucose effect within days; HbA1c by 12 weeks · Sleep effect from first dose; antidepressant effect over 1-4 weeks

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14-day course; effect persists after discontinuation in trials (1) · Monthly dosing (1) · Monthly or quarterly dosing (1)

~16-23 hours (1) · ~27 days (1) · ~31 days (1)

Adequate (food-dependent, must take with fatty meal) (1) · Not formally established (1) · Not formally established (high SC) (1)

Limited data; avoid (2) · Limited data; avoid in pregnancy. Lactation: present in milk; consider risks (1)

Rx (2) · Rx, Schedule IV (US) (1)