Drilldown: Medicines
Medicines > generic:
None 
& routes :
Intramuscular (PREEMPT injections for migraine) or
Subcutaneous
& routes :
Intramuscular (PREEMPT injections for migraine) or
Subcutaneous Use the filters below to narrow your results.
generic: (Click arrow to add another value)
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mechanism:
Cleaves SNAP-25 protein in presynaptic motor and autonomic nerve terminals, blocking acetylcholine release; in chronic migraine, hypothesized to inhibit peripheral sensitization of trigeminovascular nociceptors (1) ·
Humanized IgG2 monoclonal antibody binding both isoforms of CGRP peptide (1) ·
Humanized IgG2 monoclonal antibody binding the CGRP receptor (not the peptide); blocks CGRP-mediated vasodilation and nociceptive signaling (1) ·
Humanized IgG4 monoclonal antibody binding CGRP peptide; prevents CGRP from activating its receptor (1)
uses:
Chronic migraine (≥15 headache days/month), cervical dystonia, blepharospasm, hyperhidrosis, overactive bladder, urinary incontinence, strabismus, spasticity, cosmetic problems (1) ·
Preventive treatment of migraine in adults (episodic and chronic) (2) ·
Preventive treatment of migraine in adults; episodic cluster headache (1)
starting dose:
225 mg SC monthly, or 675 mg SC every 3 months (quarterly) (1) ·
70 mg SC monthly; may increase to 140 mg monthly (1) ·
Chronic migraine (PREEMPT protocol): 155 units divided across 31 sites in 7 head/neck muscle groups every 12 weeks (1) ·
Migraine: 240 mg SC loading dose, then 120 mg SC monthly. Cluster: 300 mg SC at onset of cluster period, then monthly during cluster. (1)
preparations:
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Showing below up to 4 results in range #1 to #4.