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Medicines > halflife : 1-1.3 hours'"`UNIQ--ref-000001A1-QINU`"' or 2–3 h (parent compound) or ~27 days

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generic:
None (2) · Amoxicillin (1) · Methylphenidate (1)
brand:
Amoxil, Trimox, Moxatag; mostly prescribed generically (1) · Emgality (1) · Ritalin, Ritalin LA, Concerta, Metadate CD, Daytrana, Quillivant XR (1) · Vyepti (1)
classes:
Anti-CGRP ligand monoclonal antibody (2) · NDRI (1) · Psychostimulant (1) · [[:Category:Aminopenicillins|Aminopenicillin]] (1) · [[:Category:Beta-lactam_antibiotics|β-lactam antibiotic]] (1) · [[:Category:Penicillins|Penicillin]] (1)
mechanism:
Humanized IgG1 monoclonal antibody binding CGRP peptide; IV infusion enables fastest onset of any CGRP mAb (1) · Humanized IgG4 monoclonal antibody binding CGRP peptide; prevents CGRP from activating its receptor (1) · Norepinephrine–dopamine reuptake inhibition (DAT, NET) (1) · '"`UNIQ--vote-00000199-QINU`"' Extends ampicillin's spectrum with better oral bioavailability. Susceptible to β-lactamases; clavulanate co-administration restores activity against many resistant organisms'"`UNIQ--ref-0000019A-QINU`"'. (1)
uses:
ADHD, narcolepsy (1) · Preventive treatment of migraine in adults (1) · Preventive treatment of migraine in adults; episodic cluster headache (1) · '"`UNIQ--vote-0000019B-QINU`"', '"`UNIQ--vote-0000019C-QINU`"', '"`UNIQ--vote-0000019D-QINU`"', '"`UNIQ--vote-0000019E-QINU`"', '"`UNIQ--vote-0000019F-QINU`"', '"`UNIQ--vote-000001A0-QINU`"' (1)
starting dose:
None (1) · 100 mg IV every 3 months; may increase to 300 mg IV every 3 months (1) · 500 mg PO TID or 875 mg PO BID for most indications; 80-90 mg/kg/d divided BID in pediatric otitis media (1) · Migraine: 240 mg SC loading dose, then 120 mg SC monthly. Cluster: 300 mg SC at onset of cluster period, then monthly during cluster. (1)
preparations:
None (1) · 100 mg/mL vial for IV infusion (1) · 120 mg/mL prefilled syringe or autoinjector (1) · 250 mg, 500 mg capsules; 500 mg, 875 mg tablets; 125, 200, 250, 400 mg/5 mL oral suspension; 775 mg ER; 50 mg/mL drops (1)
fda max:
None (1) · 240 mg loading + 120 mg/month for migraine; 300 mg/month for cluster (1) · 3 g/d typical; higher in severe infections under specialist guidance (1) · 300 mg/quarter (1)
routes:
Intravenous infusion (1) · Oral (2) · Subcutaneous (1) · transdermal (1)
onset:
20–60 min (oral) (1) · Effect demonstrated within 24 hours in some patients (1) · Over weeks (1) · Peak plasma at 1-2 hours; clinical effect within 24-72 hours (1)
duration:
3-month dosing interval (1) · IR 3–5 h; LA/SR 6–8 h; Concerta 10–12 h; Daytrana ~9 h wear time (1) · Monthly dosing (1) · ~8 hours per dose (1)
halflife: (Click arrow to add another value)
bioavailability:
100% (IV) (1) · 75-90% (oral; minimally affected by food)'"`UNIQ--ref-000001A2-QINU`"' (1) · Not formally established (high SC) (1) · ~30% (high first-pass) (1)
pregnancy:
Generally considered safe; widely used in pregnancy and lactation.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Limited data; avoid (2) · Pregnancy categories were retired by FDA in 2015. Limited reproductive data with small observational signal for cardiac malformations; risk-benefit decision, with many patients deferring ADHD treatment during pregnancy. See pregnancy_details for the full discussion. (1)
legal:
Rx (2) · Schedule II (1) · [[USLegal:Prescription only|Rx-only]] in US (1)
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