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Medicines (732)

Medicines > halflife

: 1-1.3 hours'"`UNIQ--ref-000001A1-QINU`"'

or ~5 h

or ~5 h (caffeine)

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Amoxicillin (1) · Avanafil (1) · Coffee (1) · Tea (1)

''Camellia sinensis'' (formerly ''Thea sinensis'') (1) · ''Coffea arabica'', ''Coffea canephora'' (robusta) (1) · Amoxil, Trimox, Moxatag; mostly prescribed generically (1) · Stendra (1)

Caffeine plant (2) · Excitantia (2) · PDE5 Inhibitor (1) · Plant Medicine (2) · Xanthine (1) · [[:Category:Aminopenicillins|Aminopenicillin]] (1) · [[:Category:Beta-lactam_antibiotics|β-lactam antibiotic]] (1) · [[:Category:Penicillins|Penicillin]] (1)

Caffeine + theophylline + L-theanine. L-theanine (an amino acid unique to tea) modulates glutamate and produces an 'alpha-wave' calming overlay on caffeine's stimulation, hence tea's reputation as a 'cleaner' stimulant than coffee. (1) · Caffeine is a non-selective adenosine A1/A2A receptor antagonist; also weak PDE inhibition. Beans contain theobromine (3,7-DMX) and theophylline (1,3-DMX) in smaller amounts. (1) · Selective inhibitor of phosphodiesterase type 5 (PDE5); increases cGMP in cavernous smooth muscle, producing erection in response to sexual stimulation. (1) · '"`UNIQ--vote-00000199-QINU`"' Extends ampicillin's spectrum with better oral bioavailability. Susceptible to β-lactamases; clavulanate co-administration restores activity against many resistant organisms'"`UNIQ--ref-0000019A-QINU`"'. (1)

'"`UNIQ--vote-00000040-QINU`"' (1) · '"`UNIQ--vote-000000CF-QINU`"', '"`UNIQ--vote-000000D0-QINU`"', '"`UNIQ--vote-000000D1-QINU`"' (1) · '"`UNIQ--vote-0000019B-QINU`"', '"`UNIQ--vote-0000019C-QINU`"', '"`UNIQ--vote-0000019D-QINU`"', '"`UNIQ--vote-0000019E-QINU`"', '"`UNIQ--vote-0000019F-QINU`"', '"`UNIQ--vote-000001A0-QINU`"' (1) · '"`UNIQ--vote-00000747-QINU`"', '"`UNIQ--vote-00000748-QINU`"' (1)

100 mg ~15 min before sexual activity (1) · 500 mg PO TID or 875 mg PO BID for most indications; 80-90 mg/kg/d divided BID in pediatric otitis media (1) · One cup (~40–60 mg caffeine; about half of brewed coffee) (1) · One cup (~80–145 mg caffeine for brewed; 60–100 mg for instant) (1)

250 mg, 500 mg capsules; 500 mg, 875 mg tablets; 125, 200, 250, 400 mg/5 mL oral suspension; 775 mg ER; 50 mg/mL drops (1) · 50, 100, 200 mg tabs (1) · Dried leaves, infused. Six major processings: white, green, yellow, oolong, black, pu-erh (1) · Roasted beans, ground; brewed (drip, French press, espresso, cold brew, percolated) (1)

None (2) · 200 mg/d (100 mg/d if on CYP3A4 inhibitors) (1) · 3 g/d typical; higher in severe infections under specialist guidance (1)

Oral (4)

15–30 min (1) · Peak plasma at 1-2 hours; clinical effect within 24-72 hours (1) · ~15 min (fastest of the PDE5 inhibitors) (1) · ~15–30 min (1)

3–4 h (1) · 3–5 h (subjective) (1) · 4–6 h (1) · ~8 hours per dose (1)

None (1) · 75-90% (oral; minimally affected by food)'"`UNIQ--ref-000001A2-QINU`"' (1) · Rapid absorption; absolute bioavailability not formally established (1) · ~99% (caffeine) (1)

None (1) · Category C (not relevant; not used in women) (1) · Generally considered safe; widely used in pregnancy and lactation.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1) · Limit to <200 mg/d (~2 cups brewed) (1)

None (1) · Rx-only in US (1) · Unrestricted (food) (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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