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Medicines (732)

Medicines > halflife

: 1-1.5 hours'"`UNIQ--ref-00000DE3-QINU`"'

or Not applicable (electrolyte and buffer)

or ~5 h (caffeine)

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Bumetanide (1) · Coffee (1) · Sodium bicarbonate (1) · Tea (1)

''Camellia sinensis'' (formerly ''Thea sinensis'') (1) · ''Coffea arabica'', ''Coffea canephora'' (robusta) (1) · Bumex (1) · Neut, many generic; OTC oral: Alka-Seltzer (with aspirin/citric acid), baking soda (1)

Caffeine plant (2) · Excitantia (2) · Plant Medicine (2) · Xanthine (1) · [[:Category:Antacids|Antacid]] (1) · [[:Category:Electrolyte_replacements|Electrolyte replacement]] (1) · [[:Category:Loop_diuretics|Loop diuretic]] (1)

None (1) · Caffeine + theophylline + L-theanine. L-theanine (an amino acid unique to tea) modulates glutamate and produces an 'alpha-wave' calming overlay on caffeine's stimulation, hence tea's reputation as a 'cleaner' stimulant than coffee. (1) · Caffeine is a non-selective adenosine A1/A2A receptor antagonist; also weak PDE inhibition. Beans contain theobromine (3,7-DMX) and theophylline (1,3-DMX) in smaller amounts. (1) · '"`UNIQ--vote-00000016-QINU`"' Bicarbonate is not benign: high-volume use produces hypernatremia, metabolic alkalosis, hypokalemia, and (in arrest) paradoxical intracellular acidosis'"`UNIQ--ref-00000017-QINU`"'. (1)

'"`UNIQ--vote-00000018-QINU`"', '"`UNIQ--vote-00000019-QINU`"', '"`UNIQ--vote-0000001A-QINU`"', '"`UNIQ--vote-0000001B-QINU`"', '"`UNIQ--vote-0000001C-QINU`"' (1) · '"`UNIQ--vote-000000CF-QINU`"', '"`UNIQ--vote-000000D0-QINU`"', '"`UNIQ--vote-000000D1-QINU`"' (1) · '"`UNIQ--vote-00000747-QINU`"', '"`UNIQ--vote-00000748-QINU`"' (1) · '"`UNIQ--vote-00000DDF-QINU`"', '"`UNIQ--vote-00000DE0-QINU`"', '"`UNIQ--vote-00000DE1-QINU`"', '"`UNIQ--vote-00000DE2-QINU`"' (1)

0.5-1 mg PO/IV once or twice daily; titrate to clinical response. Approximate equipotency: bumetanide 1 mg ≈ furosemide 40 mg ≈ torsemide 20 mg (1) · IV: 1 mEq/kg bolus in arrest indication, then titrated to ABG and clinical status; PO: 325-2000 mg up to QID as antacid (1) · One cup (~40–60 mg caffeine; about half of brewed coffee) (1) · One cup (~80–145 mg caffeine for brewed; 60–100 mg for instant) (1)

0.5, 1, 2 mg tablets; 0.25 mg/mL IV (1) · 4.2%, 7.5%, 8.4% IV (1 mEq/mL at 8.4%); 325, 650 mg oral tablets; bulk powder (1) · Dried leaves, infused. Six major processings: white, green, yellow, oolong, black, pu-erh (1) · Roasted beans, ground; brewed (drip, French press, espresso, cold brew, percolated) (1)

None (2) · No fixed maximum; titrated to pH and bicarbonate level; chronic high oral doses cause metabolic alkalosis and volume overload (1) · ~10 mg/d typical (1)

IM (1) · IV (2) · oral (4)

15–30 min (1) · Immediate (IV); within minutes (oral antacid) (1) · PO 30-60 minutes; IV minutes (1) · ~15–30 min (1)

3–4 h (1) · 3–5 h (subjective) (1) · 4-6 hours (1) · IV: hours, dependent on ongoing acid load; oral antacid: ~30 minutes (1)

None (1) · 100% (IV); rapidly neutralized by gastric acid (oral) (1) · ~80-95% (oral; more reliable than furosemide, comparable to torsemide)'"`UNIQ--ref-00000DE4-QINU`"' (1) · ~99% (caffeine) (1)

None (1) · Avoid where possible; class concerns as for other loop diuretics.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1) · Limit to <200 mg/d (~2 cups brewed) (1) · Routine antacid and acidosis correction acceptable (1)

None (1) · Unrestricted (food) (1) · [[USLegal:Prescription only|Rx-only]] for IV formulations; OTC for oral (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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