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Medicines > halflife : 1-2 hours'"`UNIQ--ref-00000017-QINU`"' or Not applicable (electrolyte solution) or ~27 days

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generic:
None (2) · Lactated Ringer's solution (1) · Methocarbamol (1)
brand:
Emgality (1) · Lactated Ringer's Injection (Baxter, B. Braun, ICU Medical); Hartmann's solution (intl.) (1) · Robaxin (oral, injectable) (1) · Vyepti (1)
classes:
Anti-CGRP ligand monoclonal antibody (2) · [[:Category:Crystalloid_IV_fluids|Crystalloid IV fluid]] (1) · [[:Category:Electrolyte_replacements|Electrolyte replacement]] (1) · [[:Category:Skeletal muscle relaxants|Skeletal muscle relaxant (centrally-acting)]] (1)
mechanism:
None (1) · Humanized IgG1 monoclonal antibody binding CGRP peptide; IV infusion enables fastest onset of any CGRP mAb (1) · Humanized IgG4 monoclonal antibody binding CGRP peptide; prevents CGRP from activating its receptor (1) · '"`UNIQ--vote-00000086-QINU`"' Calcium content is a relative contraindication for co-administration with citrated blood products through the same line'"`UNIQ--ref-00000087-QINU`"'. (1)
uses:
Preventive treatment of migraine in adults (1) · Preventive treatment of migraine in adults; episodic cluster headache (1) · '"`UNIQ--vote-00000015-QINU`"', '"`UNIQ--vote-00000016-QINU`"' (1) · '"`UNIQ--vote-00000088-QINU`"', '"`UNIQ--vote-00000089-QINU`"', '"`UNIQ--vote-0000008A-QINU`"', '"`UNIQ--vote-0000008B-QINU`"' (1)
starting dose:
100 mg IV every 3 months; may increase to 300 mg IV every 3 months (1) · Migraine: 240 mg SC loading dose, then 120 mg SC monthly. Cluster: 300 mg SC at onset of cluster period, then monthly during cluster. (1) · Oral: 1500 mg PO QID for 2-3 days (load), then 750-1500 mg QID maintenance. IV/IM: 1000 mg every 8 hours for acute spasm (1) · Volume titrated to clinical status; typical adult bolus 500-1000 mL, then reassess (1)
preparations:
100 mg/mL vial for IV infusion (1) · 120 mg/mL prefilled syringe or autoinjector (1) · 250, 500, 1000 mL IV bags. Composition per liter: Na+ 130 mEq, K+ 4 mEq, Ca2+ 3 mEq, Cl- 109 mEq, lactate 28 mEq (1) · Tablets 500, 750 mg; injection 100 mg/mL (1)
fda max:
240 mg loading + 120 mg/month for migraine; 300 mg/month for cluster (1) · 300 mg/quarter (1) · 8 g/day (oral, short-term load); 6 g/day (chronic) (1) · No fixed maximum; titrated to clinical endpoints (1)
routes:
intramuscular (1) · intravenous (1) · Intravenous infusion (1) · IV (1) · Oral (1) · Subcutaneous (1)
onset:
Effect demonstrated within 24 hours in some patients (1) · Immediate intravascular expansion (1) · Over weeks (1) · ~30 minutes (oral) (1)
duration:
3-month dosing interval (1) · 4-6 hours (1) · Monthly dosing (1) · Roughly 20-30% remains intravascular at 1 hour (1)
halflife: (Click arrow to add another value)
bioavailability:
100% (IV) (2) · Not formally established (high SC) (1) · ~100% (oral; near-complete absorption)'"`UNIQ--ref-00000018-QINU`"' (1)
pregnancy:
Limited data; avoid (2) · Limited human data.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Standard resuscitation fluid in pregnancy (1)
legal:
Rx (2) · [[USLegal:Prescription only|Rx-only]] in US (1) · [[USLegal:Prescription only|Rx-only]] in US. Not a controlled substance, distinguishing it from carisoprodol which is Schedule IV'"`UNIQ--ref-00000019-QINU`"' (1)
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