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Medicines > halflife : 1-3 minutes (very short)'"`UNIQ--ref-00000C0F-QINU`"' or ~11 h or ~27 days

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generic:
None (2) · Flibanserin (1) · Nitroglycerin (glyceryl trinitrate, GTN) (1)
brand:
Addyi (1) · Emgality (1) · Nitrostat, Nitrolingual, NitroMist, Nitro-Bid, Nitro-Dur, Minitran, Rectiv (1) · Vyepti (1)
classes:
Anti-CGRP ligand monoclonal antibody (2) · Multimodal serotonergic; HSDD treatment (1) · [[:Category:Antianginals|Antianginal]] (1) · [[:Category:Nitrates|Organic nitrate]] (1) · [[:Category:Vasodilators|Vasodilator]] (1)
mechanism:
None (1) · 5-HT1A agonist, 5-HT2A antagonist, with weaker activity at D4 and other receptors. Net effect involves enhanced prefrontal dopaminergic/noradrenergic tone with decreased serotonergic inhibition of sexual desire. (1) · Humanized IgG1 monoclonal antibody binding CGRP peptide; IV infusion enables fastest onset of any CGRP mAb (1) · Humanized IgG4 monoclonal antibody binding CGRP peptide; prevents CGRP from activating its receptor (1)
uses:
Preventive treatment of migraine in adults (1) · Preventive treatment of migraine in adults; episodic cluster headache (1) · '"`UNIQ--vote-000002C1-QINU`"' (1) · '"`UNIQ--vote-00000C0A-QINU`"', '"`UNIQ--vote-00000C0B-QINU`"', '"`UNIQ--vote-00000C0C-QINU`"', '"`UNIQ--vote-00000C0D-QINU`"', '"`UNIQ--vote-00000C0E-QINU`"' (1)
starting dose:
100 mg at bedtime daily (1) · 100 mg IV every 3 months; may increase to 300 mg IV every 3 months (1) · Migraine: 240 mg SC loading dose, then 120 mg SC monthly. Cluster: 300 mg SC at onset of cluster period, then monthly during cluster. (1) · SL 0.3-0.6 mg every 5 minutes up to 3 doses for acute angina (call EMS if not resolved after the third); IV infusion 5-10 mcg/min titrated; transdermal patch 0.2-0.4 mg/hr for 12-14 hours daily (nitrate-free interval prevents tolerance) (1)
preparations:
100 mg tabs (1) · 100 mg/mL vial for IV infusion (1) · 120 mg/mL prefilled syringe or autoinjector (1) · SL 0.3, 0.4, 0.6 mg tablets; lingual spray 0.4 mg/spray; ER 2.5-9 mg capsules; transdermal patch 0.1-0.8 mg/hr; 2% ointment; 0.4% rectal ointment; 5 mg/mL IV (1)
fda max:
100 mg/d (1) · 240 mg loading + 120 mg/month for migraine; 300 mg/month for cluster (1) · 300 mg/quarter (1) · Indication-specific; titrated to effect (1)
routes:
Intravenous infusion (1) · IV (1) · lingual spray (1) · Oral (1) · oral ER (1) · rectal (1) · Subcutaneous (1) · Sublingual (1) · topical (1) · transdermal (1)
onset:
Effect demonstrated within 24 hours in some patients (1) · Effects accumulate over weeks; assess at 8 weeks (1) · Over weeks (1) · SL/spray: 1-3 minutes; IV: minutes; patch: 30-60 minutes (1)
duration:
3-month dosing interval (1) · Continuous daily dosing (1) · Monthly dosing (1) · SL: 30 minutes; patch: 12-14 hours; IV continuous (1)
halflife: (Click arrow to add another value)
bioavailability:
100% (IV) (1) · Highly route-dependent: SL bypasses first-pass; oral has extensive first-pass (used only for chronic ER preparations); transdermal predictable'"`UNIQ--ref-00000C10-QINU`"' (1) · Not formally established (high SC) (1) · ~33% (1)
pregnancy:
Limited data; avoid (2) · Not indicated; pregnancy effects unknown (1) · Used in obstetric emergencies (uterine relaxation, severe hypertension) when needed; otherwise limited routine use.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
Rx (2) · Rx-only in US (REMS program) (1) · [[USLegal:Prescription only|Rx-only]] in US (1)
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