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Medicines > halflife : 1.5-2 hours (longer in renal failure)'"`UNIQ--ref-00000222-QINU`"' or Not applicable (electrolyte solution) or ~27 days

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generic:
None (2) · Furosemide (1) · Lactated Ringer's solution (1)
brand:
Emgality (1) · Lactated Ringer's Injection (Baxter, B. Braun, ICU Medical); Hartmann's solution (intl.) (1) · Lasix (1) · Vyepti (1)
classes:
Anti-CGRP ligand monoclonal antibody (2) · [[:Category:Crystalloid_IV_fluids|Crystalloid IV fluid]] (1) · [[:Category:Diuretics|Diuretic]] (1) · [[:Category:Electrolyte_replacements|Electrolyte replacement]] (1) · [[:Category:Loop_diuretics|Loop diuretic]] (1)
mechanism:
None (1) · Humanized IgG1 monoclonal antibody binding CGRP peptide; IV infusion enables fastest onset of any CGRP mAb (1) · Humanized IgG4 monoclonal antibody binding CGRP peptide; prevents CGRP from activating its receptor (1) · '"`UNIQ--vote-00000086-QINU`"' Calcium content is a relative contraindication for co-administration with citrated blood products through the same line'"`UNIQ--ref-00000087-QINU`"'. (1)
uses:
Preventive treatment of migraine in adults (1) · Preventive treatment of migraine in adults; episodic cluster headache (1) · '"`UNIQ--vote-00000088-QINU`"', '"`UNIQ--vote-00000089-QINU`"', '"`UNIQ--vote-0000008A-QINU`"', '"`UNIQ--vote-0000008B-QINU`"' (1) · '"`UNIQ--vote-0000021C-QINU`"', '"`UNIQ--vote-0000021D-QINU`"', '"`UNIQ--vote-0000021E-QINU`"', '"`UNIQ--vote-0000021F-QINU`"', '"`UNIQ--vote-00000220-QINU`"', '"`UNIQ--vote-00000221-QINU`"' (1)
starting dose:
100 mg IV every 3 months; may increase to 300 mg IV every 3 months (1) · 20-40 mg PO/IV; titrate by clinical response. In diuretic-resistant heart failure or CKD, doses to 200 mg or higher may be needed (1) · Migraine: 240 mg SC loading dose, then 120 mg SC monthly. Cluster: 300 mg SC at onset of cluster period, then monthly during cluster. (1) · Volume titrated to clinical status; typical adult bolus 500-1000 mL, then reassess (1)
preparations:
100 mg/mL vial for IV infusion (1) · 120 mg/mL prefilled syringe or autoinjector (1) · 20, 40, 80 mg tablets; 10 mg/mL oral solution; 10 mg/mL IV (1) · 250, 500, 1000 mL IV bags. Composition per liter: Na+ 130 mEq, K+ 4 mEq, Ca2+ 3 mEq, Cl- 109 mEq, lactate 28 mEq (1)
fda max:
240 mg loading + 120 mg/month for migraine; 300 mg/month for cluster (1) · 300 mg/quarter (1) · 600 mg/d typical practical ceiling in heart failure (1) · No fixed maximum; titrated to clinical endpoints (1)
routes:
IM (1) · Intravenous infusion (1) · IV (2) · Oral (1) · Subcutaneous (1)
onset:
Effect demonstrated within 24 hours in some patients (1) · Immediate intravascular expansion (1) · IV: 5 minutes; PO: 30-60 minutes (1) · Over weeks (1)
duration:
3-month dosing interval (1) · IV: ~2 hours; PO: 6-8 hours (1) · Monthly dosing (1) · Roughly 20-30% remains intravascular at 1 hour (1)
halflife: (Click arrow to add another value)
bioavailability:
100% (IV) (2) · Not formally established (high SC) (1) · ~50% (oral; highly variable, 10-100%, hence the standard 1:2 IV-to-PO conversion)'"`UNIQ--ref-00000223-QINU`"' (1)
pregnancy:
Avoid where possible; can reduce uteroplacental perfusion and produce neonatal electrolyte disturbance. Reserved for compelling indications.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Limited data; avoid (2) · Standard resuscitation fluid in pregnancy (1)
legal:
Rx (2) · [[USLegal:Prescription only|Rx-only]] in US (2)
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