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Medicines > routes: IV & halflife : 1.5-2 hours (longer in renal failure)'"`UNIQ--ref-00000222-QINU`"' or Not applicable (electrolyte solution)

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generic:
Furosemide (1) · Lactated Ringer's solution (1)
brand:
Lactated Ringer's Injection (Baxter, B. Braun, ICU Medical); Hartmann's solution (intl.) (1) · Lasix (1)
classes:
[[:Category:Crystalloid_IV_fluids|Crystalloid IV fluid]] (1) · [[:Category:Diuretics|Diuretic]] (1) · [[:Category:Electrolyte_replacements|Electrolyte replacement]] (1) · [[:Category:Loop_diuretics|Loop diuretic]] (1)
mechanism:
None (1) · '"`UNIQ--vote-00000086-QINU`"' Calcium content is a relative contraindication for co-administration with citrated blood products through the same line'"`UNIQ--ref-00000087-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000088-QINU`"', '"`UNIQ--vote-00000089-QINU`"', '"`UNIQ--vote-0000008A-QINU`"', '"`UNIQ--vote-0000008B-QINU`"' (1) · '"`UNIQ--vote-0000021C-QINU`"', '"`UNIQ--vote-0000021D-QINU`"', '"`UNIQ--vote-0000021E-QINU`"', '"`UNIQ--vote-0000021F-QINU`"', '"`UNIQ--vote-00000220-QINU`"', '"`UNIQ--vote-00000221-QINU`"' (1)
starting dose:
20-40 mg PO/IV; titrate by clinical response. In diuretic-resistant heart failure or CKD, doses to 200 mg or higher may be needed (1) · Volume titrated to clinical status; typical adult bolus 500-1000 mL, then reassess (1)
preparations:
20, 40, 80 mg tablets; 10 mg/mL oral solution; 10 mg/mL IV (1) · 250, 500, 1000 mL IV bags. Composition per liter: Na+ 130 mEq, K+ 4 mEq, Ca2+ 3 mEq, Cl- 109 mEq, lactate 28 mEq (1)
fda max:
600 mg/d typical practical ceiling in heart failure (1) · No fixed maximum; titrated to clinical endpoints (1)
routes: (Click arrow to add another value)
onset:
Immediate intravascular expansion (1) · IV: 5 minutes; PO: 30-60 minutes (1)
duration:
IV: ~2 hours; PO: 6-8 hours (1) · Roughly 20-30% remains intravascular at 1 hour (1)
halflife: (Click arrow to add another value)
bioavailability:
100% (IV) (1) · ~50% (oral; highly variable, 10-100%, hence the standard 1:2 IV-to-PO conversion)'"`UNIQ--ref-00000223-QINU`"' (1)
pregnancy:
Avoid where possible; can reduce uteroplacental perfusion and produce neonatal electrolyte disturbance. Reserved for compelling indications.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Standard resuscitation fluid in pregnancy (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (2)
Error in "where" parameter: the string "--" cannot be used within #cargo_query.

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