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Medicines (732)

Medicines > halflife

: 1.5-2 hours (longer in renal failure)'"`UNIQ--ref-00000222-QINU`"'

or ~12 hours

or ~5 h (caffeine)

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None (1) · Coffee (1) · Duloxetine (1) · Furosemide (1) · Tea (1)

''Camellia sinensis'' (formerly ''Thea sinensis'') (1) · ''Coffea arabica'', ''Coffea canephora'' (robusta) (1) · Belsomra (1) · Cymbalta, Drizalma Sprinkle, Irenka, Yentreve (1) · Lasix (1)

Antidepressant (1) · Anxiolytic (1) · Caffeine plant (2) · Dual orexin receptor antagonist (DORA) (1) · Excitantia (2) · Plant Medicine (2) · SNRI (1) · the first approved (1) · Xanthine (1) · [[:Category:Diuretics|Diuretic]] (1) · [[:Category:Loop_diuretics|Loop diuretic]] (1)

None (1) · Caffeine + theophylline + L-theanine. L-theanine (an amino acid unique to tea) modulates glutamate and produces an 'alpha-wave' calming overlay on caffeine's stimulation, hence tea's reputation as a 'cleaner' stimulant than coffee. (1) · Caffeine is a non-selective adenosine A1/A2A receptor antagonist; also weak PDE inhibition. Beans contain theobromine (3,7-DMX) and theophylline (1,3-DMX) in smaller amounts. (1) · Competitive antagonist at OX1R and OX2R. First-in-class DORA. Receptor dissociation slower than lemborexant or daridorexant. (1) · Serotonin–norepinephrine reuptake inhibition (balanced) (1)

Depression, anxiety, neuropathic pain, fibromyalgia, chronic musculoskeletal pain (1) · Insomnia (sleep onset and/or maintenance) in adults (FDA-approved August 2014). Also studied for insomnia in mild-moderate Alzheimer disease. (1) · '"`UNIQ--vote-000000CF-QINU`"', '"`UNIQ--vote-000000D0-QINU`"', '"`UNIQ--vote-000000D1-QINU`"' (1) · '"`UNIQ--vote-0000021C-QINU`"', '"`UNIQ--vote-0000021D-QINU`"', '"`UNIQ--vote-0000021E-QINU`"', '"`UNIQ--vote-0000021F-QINU`"', '"`UNIQ--vote-00000220-QINU`"', '"`UNIQ--vote-00000221-QINU`"' (1) · '"`UNIQ--vote-00000747-QINU`"', '"`UNIQ--vote-00000748-QINU`"' (1)

None (1) · 10 mg PO 30 min before bedtime (with ≥7 hours of sleep planned) (1) · 20-40 mg PO/IV; titrate by clinical response. In diuretic-resistant heart failure or CKD, doses to 200 mg or higher may be needed (1) · One cup (~40–60 mg caffeine; about half of brewed coffee) (1) · One cup (~80–145 mg caffeine for brewed; 60–100 mg for instant) (1)

None (1) · 20, 40, 80 mg tablets; 10 mg/mL oral solution; 10 mg/mL IV (1) · 5 mg, 10 mg, 15 mg, 20 mg tablets (1) · Dried leaves, infused. Six major processings: white, green, yellow, oolong, black, pu-erh (1) · Roasted beans, ground; brewed (drip, French press, espresso, cold brew, percolated) (1)

None (3) · 20 mg/d (1) · 600 mg/d typical practical ceiling in heart failure (1)

IM (1) · IV (1) · Oral (5)

15–30 min (1) · IV: 5 minutes; PO: 30-60 minutes (1) · Mood: 2–4 weeks. Pain: often within 1–2 weeks. (1) · ~15–30 min (1) · ~30 min (1)

3–4 h (1) · 3–5 h (subjective) (1) · Chronic daily dosing (1) · IV: ~2 hours; PO: 6-8 hours (1) · ~7-8 hours (1)

None (1) · ~50% (highly variable) (1) · ~50% (oral; highly variable, 10-100%, hence the standard 1:2 IV-to-PO conversion)'"`UNIQ--ref-00000223-QINU`"' (1) · ~82% (1) · ~99% (caffeine) (1)

None (1) · Avoid where possible; can reduce uteroplacental perfusion and produce neonatal electrolyte disturbance. Reserved for compelling indications.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1) · Category C (1) · Limit to <200 mg/d (~2 cups brewed) (1) · Limited data; avoid (1)

None (1) · Rx, Schedule IV (US) (1) · Rx-only (1) · Unrestricted (food) (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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