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Medicines > halflife : 11-15 hours'"`UNIQ--ref-00000842-QINU`"' or Not applicable (electrolyte solution) or ~27 days

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generic:
None (2) · Irbesartan (1) · Lactated Ringer's solution (1)
brand:
Avapro (1) · Emgality (1) · Lactated Ringer's Injection (Baxter, B. Braun, ICU Medical); Hartmann's solution (intl.) (1) · Vyepti (1)
classes:
Anti-CGRP ligand monoclonal antibody (2) · [[:Category:Angiotensin_receptor_blockers|Angiotensin receptor blocker (ARB)]] (1) · [[:Category:Antihypertensives|Antihypertensive]] (1) · [[:Category:Crystalloid_IV_fluids|Crystalloid IV fluid]] (1) · [[:Category:Electrolyte_replacements|Electrolyte replacement]] (1)
mechanism:
Humanized IgG1 monoclonal antibody binding CGRP peptide; IV infusion enables fastest onset of any CGRP mAb (1) · Humanized IgG4 monoclonal antibody binding CGRP peptide; prevents CGRP from activating its receptor (1) · '"`UNIQ--vote-00000086-QINU`"' Calcium content is a relative contraindication for co-administration with citrated blood products through the same line'"`UNIQ--ref-00000087-QINU`"'. (1) · '"`UNIQ--vote-0000083E-QINU`"' CYP2C9 substrate; no clinically active metabolites. The IDNT trial established renoprotection in diabetic nephropathy independent of BP lowering, contributing to the ARB class indication in T2DM with proteinuria'"`UNIQ--ref-0000083F-QINU`"'. (1)
uses:
Preventive treatment of migraine in adults (1) · Preventive treatment of migraine in adults; episodic cluster headache (1) · '"`UNIQ--vote-00000088-QINU`"', '"`UNIQ--vote-00000089-QINU`"', '"`UNIQ--vote-0000008A-QINU`"', '"`UNIQ--vote-0000008B-QINU`"' (1) · '"`UNIQ--vote-00000840-QINU`"', '"`UNIQ--vote-00000841-QINU`"' (1)
starting dose:
100 mg IV every 3 months; may increase to 300 mg IV every 3 months (1) · 150 mg PO once daily; titrate to 300 mg if needed (1) · Migraine: 240 mg SC loading dose, then 120 mg SC monthly. Cluster: 300 mg SC at onset of cluster period, then monthly during cluster. (1) · Volume titrated to clinical status; typical adult bolus 500-1000 mL, then reassess (1)
preparations:
100 mg/mL vial for IV infusion (1) · 120 mg/mL prefilled syringe or autoinjector (1) · 250, 500, 1000 mL IV bags. Composition per liter: Na+ 130 mEq, K+ 4 mEq, Ca2+ 3 mEq, Cl- 109 mEq, lactate 28 mEq (1) · 75, 150, 300 mg tablets (1)
fda max:
240 mg loading + 120 mg/month for migraine; 300 mg/month for cluster (1) · 300 mg/d (1) · 300 mg/quarter (1) · No fixed maximum; titrated to clinical endpoints (1)
routes:
Intravenous infusion (1) · IV (1) · Oral (1) · Subcutaneous (1)
onset:
BP effect within 1-2 weeks (1) · Effect demonstrated within 24 hours in some patients (1) · Immediate intravascular expansion (1) · Over weeks (1)
duration:
24 hours (1) · 3-month dosing interval (1) · Monthly dosing (1) · Roughly 20-30% remains intravascular at 1 hour (1)
halflife: (Click arrow to add another value)
bioavailability:
100% (IV) (2) · 60-80% (oral; not significantly affected by food)'"`UNIQ--ref-00000843-QINU`"' (1) · Not formally established (high SC) (1)
pregnancy:
'''Contraindicated in pregnancy''' (all trimesters); fetal renal injury, oligohydramnios, hypocalvaria, hypotension. Stop on detection'"`UNIQ--ref-00000844-QINU`"' (1) · Limited data; avoid (2) · Standard resuscitation fluid in pregnancy (1)
legal:
Rx (2) · [[USLegal:Prescription only|Rx-only]] in US (2)
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