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Medicines > routes: IM & halflife: Plasma 2-3 hours; biologic ~18-36 hours'"`UNIQ--ref-000008C4-QINU`"'

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generic:
Prednisolone (and prednisolone sodium phosphate, acetate, etc.) (1)
brand:
Prelone, Pediapred, Orapred ODT, Millipred, Veripred (1)
classes:
[[:Category:Corticosteroids|Corticosteroid]] (1) · [[:Category:Glucocorticoids|Glucocorticoid (intermediate-acting)]] (1) · [[:Category:Immunosuppressants|Immunosuppressant]] (1)
mechanism:
'"`UNIQ--vote-000008BE-QINU`"' Preferred over prednisone in advanced hepatic dysfunction where hepatic 11β-HSD1 activation is impaired. Liquid formulations are the workhorse pediatric oral corticosteroid for asthma and croup'"`UNIQ--ref-000008BF-QINU`"'. (1)
uses:
'"`UNIQ--vote-000008C0-QINU`"', '"`UNIQ--vote-000008C1-QINU`"', '"`UNIQ--vote-000008C2-QINU`"', '"`UNIQ--vote-000008C3-QINU`"' (1)
starting dose:
Pediatric 1-2 mg/kg/d (max 60 mg) PO for asthma exacerbation; adult dosing similar to prednisone milligram-for-milligram (~1:1 potency) (1)
preparations:
5 mg tablets; 5 mg/5 mL, 10 mg/5 mL, 15 mg/5 mL oral solutions (sweetened pediatric); 5 mg/5 mL syrup; ophthalmic 0.12%, 1% suspensions and 1% solution (1)
fda max:
Indication-specific (1)
routes: (Click arrow to add another value)
onset:
Hours (1)
duration:
Biologic 12-36 hours (intermediate-acting) (1)
halflife: (Click arrow to add another value)
bioavailability:
~70% (oral)'"`UNIQ--ref-000008C5-QINU`"' (1)
pregnancy:
Use when benefits outweigh; small association with oral clefts debated.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)
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