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Medicines > halflife: None & legal : Currently legal in most jurisdictions with thujone limits or Leaves legal in Bolivia, Peru, Colombia; cocaine internationally controlled

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generic:
Artemisia absinthium (1) · Coca (1)
brand:
''Erythroxylum coca'', ''E. novogranatense'' (1) · Wormwood, absinthe, la Fée Verte, the Green Muse (1)
classes:
Excitantia (1) · Plant Medicine (2) · Rhapsodica (1)
mechanism:
Active principle is thujone, a GABA-A antagonist (the opposite of most CNS depressants). Also present in cooking sage (''Salvia officinalis''), tansy, and ''Thuja'' cedars. (1) · Primary alkaloid is cocaine, a tropane that blocks reuptake of dopamine and norepinephrine (and serotonin). At low oral doses from leaf chewing, the slow release favors NE-mediated alertness over DA-mediated euphoria. (1)
uses:
'"`UNIQ--vote-00000008-QINU`"', '"`UNIQ--vote-00000009-QINU`"' (1) · '"`UNIQ--vote-0000000C-QINU`"', '"`UNIQ--vote-0000000D-QINU`"', '"`UNIQ--vote-0000000E-QINU`"', '"`UNIQ--vote-0000000F-QINU`"' (1)
starting dose:
None (1) · A measured pour of absinthe diluted 5:1 with cold water over sugar (the louche ritual) (1)
preparations:
Dried leaves; absinthe liqueur (120–160 proof, with hyssop, lemon balm, fennel, anise, sometimes Acorus calamus) (1) · Leaves chewed with a pinch of slaked lime (the lime converts cocaine HCl to freebase for buccal absorption); also drunk as tea (''mate de coca'') (1)
fda max:
None (2)
routes:
buccal); refined cocaine has its own profile (1) · Oral (1) · Oral (leaf (1)
onset:
None (2)
duration:
None (2)
halflife: (Click arrow to add another value)
bioavailability:
None (2)
pregnancy:
None (2)
legal: (Click arrow to add another value)

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