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Drilldown: Medicines

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Medicines > pregnancy: None & legal : Leaves legal in Bolivia, Peru, Colombia; cocaine internationally controlled or [[USLegal:DEA Schedule I|Schedule I]] (United States)

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generic:
Coca (1) · DMT (1)
brand:
None (1) · ''Erythroxylum coca'', ''E. novogranatense'' (1)
classes:
Excitantia (1) · Plant Medicine (1) · [[:Category:Classical Psychedelics (Serotonergic)|Classic Psychedelic]] (1) · [[:Category:Tryptamines|Tryptamine]] (1)
mechanism:
5-HT2A partial agonist; sigma-1 agonist (1) · Primary alkaloid is cocaine, a tropane that blocks reuptake of dopamine and norepinephrine (and serotonin). At low oral doses from leaf chewing, the slow release favors NE-mediated alertness over DA-mediated euphoria. (1)
uses:
None (1) · '"`UNIQ--vote-0000000C-QINU`"', '"`UNIQ--vote-0000000D-QINU`"', '"`UNIQ--vote-0000000E-QINU`"', '"`UNIQ--vote-0000000F-QINU`"' (1)
starting dose:
None (2)
preparations:
None (1) · Leaves chewed with a pinch of slaked lime (the lime converts cocaine HCl to freebase for buccal absorption); also drunk as tea (''mate de coca'') (1)
fda max:
None (2)
routes:
None (1) · buccal); refined cocaine has its own profile (1) · Oral (leaf (1)
onset:
None (2)
duration:
None (1) · About 20 minutes (1)
halflife:
None (1) · 9–12 minutes (intravenous) (1)
bioavailability:
None (2)
pregnancy: (Click arrow to add another value)
legal: (Click arrow to add another value)

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