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Medicines (732)
Medicines
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legal:
Investigational
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generic:
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None
·
Oral
·
IV
·
topical
·
IM
·
intranasal
·
rectal
·
Subcutaneous
·
Topical ophthalmic
·
ophthalmic
·
intramuscular
·
intravenous
·
transdermal
·
vaginal
·
Subcutaneous (abdomen
·
sublingual
·
thigh
·
Inhaled
·
intra-articular
·
nebulized
Other values:
IA
IM (benzathine
IM (estradiol valerate
IM (not for IV)
IM (rare
IV (Revatio)
IV (aqueous crystalline); '''NEVER IV for benzathine — fatal cardiopulmonary events reported'''
IV (continuous infusion for DKA)
IV (gluconate or chloride for acute use)
IV (prednisolone sodium phosphate)
IV (rare)
IV (rarely used; same dose)
IV (with caution)
IV infusion (60 min) every 2 weeks; outpatient or infusion-center setting
IV infusion every 4 weeks
Inhalation (vaporized)
Inhaled (DPI
Inhaled (MDI
Intramuscular (PREEMPT injections for migraine)
Intranasal (under direct medical supervision)
Intravenous (continuous infusion in a REMS-certified facility)
Intravenous infusion
MI reports)
NeoProfen)
Oral (IR
Oral (IR and multiple ER)
Oral (IV form withdrawn US 2009 due to fatal toxicity reports)
Oral (buccal absorption)
Oral (buccal)
Oral (capsule whole or opened/sprinkled on applesauce)
Oral (continuation only)
Oral (leaf
Oral (must be taken in bed; effects within minutes)
Oral (prescribed)
Oral (sublingual disintegration)
Oral (swallow whole)
Oral (topical action; minimal systemic absorption)
Oral (with MAOI)
Oral; sublingual IR is discouraged (uncontrolled BP drops
PO (only formulation marketed in the US).
PR
SC
SC (less common)
Subcutaneous (never IV; not for use in insulin pumps)
Sublingual film or tablet (buccal for some)
Topical (cream
Topical (gel/patch)
buccal
buccal); refined cocaine has its own profile
cypionate)
endotracheal (legacy ACLS
epidural
epidural injection
especially in acute HE)
for severe malabsorption)
gel); oral (restricted)
infiltration
inhalation
insufflated
insulin pumps
intracardiac (historical only)
intralesional
intramuscular (LAI)
intramuscular (acute and long-acting)
intranasal sinus implant
intranasal; rectal and IV reported.
intrathecal
intrathecal (rare and controversial)
intrathecal (rare)
intrathecal (via implanted infusion pump)
intravenous (Caldolor
intravenous (PDA closure only)
intravesical
intravitreal
lingual spray
multiple ER formulations)
nasal
nebulized)
nerve block)
not preferred)
on empty stomach with ≤120 mL water
oral (APL only)
oral (enteric-coated
oral (undecanoate only)
oral ER
oral mucosal
oral paste
oral powder (Cambia for migraine)
oral rinse (do not swallow)
oral troche
oromucosal spray
otic
procaine)
rectal (enema
rectal (off-label use of injection)
rectal foam)
regional anesthesia (spinal
shampoo
smoked
smoked (extracted DMT)
soft-mist inhaler)
subcutaneous (LAI)
sublingual (dinitrate)
topical gel
topical skin
upper arm); same time each day
upper arm)'"`UNIQ--ref-00000056-QINU`"'
upper arm)'"`UNIQ--ref-000000E9-QINU`"'
upper arm)'"`UNIQ--ref-0000024E-QINU`"' · Oral (Rybelsus only
upper arm)'"`UNIQ--ref-00000300-QINU`"'
with or without food'"`UNIQ--ref-00000187-QINU`"'
≥30 min before any food/drink/other oral medicine)'"`UNIQ--ref-0000024F-QINU`"'
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onset:
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legal:
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None
·
[[USLegal:Prescription only|Rx-only]] in US
·
OTC in US
·
Rx
·
Rx-only in US
·
Rx, Schedule IV (US)
·
Schedule II
·
[[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-00000028-QINU`"'
·
Rx-only
·
[[USLegal:DEA Schedule I|Schedule I]] (United States)
·
[[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-00000022-QINU`"'
·
[[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-00000025-QINU`"'
·
[[USLegal:Schedule IV|Schedule IV controlled substance]] in US. Carries the benzodiazepine class '''Boxed Warning''' for risk of fatal respiratory depression, coma, and death when combined with opioids'"`UNIQ--ref-00000028-QINU`"'
·
'''[[USLegal:Behind-the-counter|Behind-the-counter]] in US''' under the Combat Methamphetamine Epidemic Act 2005: purchase restricted to ≤3.6 g/day and ≤9 g/30 days, with photo ID, logbook signature, and quantity logging required. Several states schedule higher than federal
·
'''[[USLegal:Schedule V|Schedule V controlled substance]] in US (federally)''', distinct from gabapentin which remains federally unscheduled'"`UNIQ--ref-00000028-QINU`"'
·
5-MeO-DMT is Schedule I in US (since 2011); the toad itself is protected in several southwestern states
·
Currently legal in most jurisdictions with thujone limits
· Investigational ·
Leaves legal in Bolivia, Peru, Colombia; cocaine internationally controlled
·
OTC (1% shampoo) and [[USLegal:Prescription only|Rx-only]] (higher strengths, oral) in US. Oral form carries a '''Boxed Warning''' for hepatotoxicity and is restricted by FDA to refractory fungal infections where no alternatives are available
Other values:
OTC (10-20 mg) and [[USLegal:Prescription only|Rx-only]] (higher doses) in US
OTC (20 mg) and [[USLegal:Prescription only|Rx-only]] (higher doses) in US
OTC (20 mg, 14-day course) and [[USLegal:Prescription only|Rx-only]] (higher and longer durations) in US
OTC (Astepro 0.15%) and [[USLegal:Prescription only|Rx-only]] (other intranasal, ophthalmic, Dymista) in US
OTC (MiraLAX) and [[USLegal:Prescription only|Rx-only]] (electrolyte solutions for bowel prep) in US
OTC (Nasonex 24HR) and [[USLegal:Prescription only|Rx-only]] (other forms) in US
OTC (Pataday ophthalmic) and [[USLegal:Prescription only|Rx-only]] (Patanase intranasal) in US
OTC (intranasal Flonase) and [[USLegal:Prescription only|Rx-only]] (inhaled, topical) in US
OTC (intranasal Rhinocort Allergy) and [[USLegal:Prescription only|Rx-only]] (other forms) in US
OTC (low-dose topicals) and [[USLegal:Prescription only|Rx-only]] (other forms) in US
OTC (low-dose) and [[USLegal:Prescription only|Rx-only]] (1 mg, injectable) in US
OTC (low-dose) and [[USLegal:Prescription only|Rx-only]] (50,000 IU and concentrated solutions) in US
OTC (low-dose, dietary supplement) and [[USLegal:Prescription only|Rx-only]] (Niaspan ER) in US
OTC (low/mid-dose oral) and [[USLegal:Prescription only|Rx-only]] (injection, intranasal) in US
OTC (lower doses) and [[USLegal:Prescription only|Rx-only]] (higher doses) in US
OTC (lower strengths) and [[USLegal:Prescription only|Rx-only]] (combination with betamethasone) in US
OTC (lower-concentration washes) and [[USLegal:Prescription only|Rx-only]] (Peridex oral rinse, ChloraPrep) in US
OTC (lowest-strength topicals) and [[USLegal:Prescription only|Rx-only]] (higher strengths, injectable) in US
OTC (most dentifrice and rinse) and [[USLegal:Prescription only|Rx-only]] (high-concentration paste/gel, supplements) in US
OTC (most) and [[USLegal:Prescription only|Rx-only]] (50,000 IU) in US
OTC (ophthalmic ointment) and [[USLegal:Prescription only|Rx-only]] (other forms) in US
OTC (oral salts) and [[USLegal:Prescription only|Rx-only]] (IV) in US
OTC (oral supplements) and [[USLegal:Prescription only|Rx-only]] (IV) in US
OTC (topical) and [[USLegal:Prescription only|Rx-only]] (oral) in US
OTC (transdermal patch in women) and [[USLegal:Prescription only|Rx-only]] (other forms) in US
OTC and [[USLegal:Prescription only|Rx-only]] (IV, combination products) in US
Plant unrestricted; pharmaceutical atropine Rx-only
Rx, '''not a controlled substance''' (no DEA scheduling)
Rx, '''not a controlled substance''' (unique among wake-promoting agents)
Rx, Schedule III (US). REMS program required.
Rx-only in US (REMS program)
Rx-only;'"`UNIQ--ref-0000005C-QINU`"' not a controlled substance
Rx-only;'"`UNIQ--ref-000000F0-QINU`"' not a controlled substance
Rx-only;'"`UNIQ--ref-0000018D-QINU`"' not a controlled substance
Rx-only;'"`UNIQ--ref-00000256-QINU`"' not a controlled substance
Rx-only;'"`UNIQ--ref-00000305-QINU`"' not a controlled substance
Rx. FDA black-box warning for increased mortality in elderly patients with dementia-related psychosis (class warning shared with all antipsychotics)
Rx; ARIA monitoring required
Rx; REMS program required (excessive sedation/loss of consciousness during infusion)
Rx; REMS-like program for ARIA monitoring
Rx; black-box warning for distant spread of toxin effect
Schedule I (United States)
Schedule I in US since 1993 (despite traditional use elsewhere); legal in Ethiopia, Kenya, Yemen, Somalia, Djibouti
Schedule III (DEA, US)
Schedule III in US; X-waiver no longer required (as of 2023)
Schedule III; REMS-restricted (Schedule I if outside the pharmaceutical channel, same molecule as illicit GHB)
Schedule IV (US)
US Schedule II (single-entity); Schedule III–V (combination products by content).
Unrestricted (food)
Withdrawn from US market January 2024
[[USLegal:DEA Schedule II|Schedule II]] controlled substance in US (rescheduled from Schedule III in 1978). No accepted medical use. UN Convention on Psychotropic Substances Schedule II internationally.'"`UNIQ--ref-00000067-QINU`"'
[[USLegal:Over-the-counter|OTC]] as Bonine and Dramamine Less Drowsy; [[USLegal:Prescription only|Rx-only]] as Antivert
[[USLegal:Over-the-counter|OTC]] dietary supplement in the US ('''not FDA-regulated as a medicine'''; multiple studies show OTC products contain 50-470% of labeled melatonin content); [[USLegal:Prescription only|Rx-only]] in the EU and UK
[[USLegal:Over-the-counter|OTC]] for most oral and topical formulations; [[USLegal:Prescription only|Rx-only]] for injectable
[[USLegal:Over-the-counter|OTC]] in US at all standard strengths
[[USLegal:Over-the-counter|OTC]] in US at ≤220 mg/tablet and ≤660 mg/day; [[USLegal:Prescription only|Rx-only]] at higher strengths
[[USLegal:Over-the-counter|OTC]] in the US at ≤200 mg per tablet / ≤1200 mg/day; [[USLegal:Prescription only|Rx-only]] at higher strengths and indications
[[USLegal:Prescription only|Prescription only]]; not a controlled substance
[[USLegal:Prescription only|Rx-only]] (higher concentrations and IV) and OTC (low-dose supplements) in US
[[USLegal:Prescription only|Rx-only]] for IV formulations; OTC for oral
[[USLegal:Prescription only|Rx-only]] for most formulations; some low-concentration topical formulations are [[USLegal:Over-the-counter|OTC]] (4% cream)
[[USLegal:Prescription only|Rx-only]] for oral and most topical formulations in US; Voltaren Arthritis Pain 1% gel switched to [[USLegal:Over-the-counter|OTC]] in 2020
[[USLegal:Prescription only|Rx-only]] for parenteral formulations; OTC for oral, nasal, and many nebulizer products
[[USLegal:Prescription only|Rx-only]] in US (most products; some low-volume packs OTC)
[[USLegal:Prescription only|Rx-only]] in US (note: norgestrel 0.075 mg POP is now OTC as Opill since 2023, but norethindrone POP remains Rx)
[[USLegal:Prescription only|Rx-only]] in US (some OTC formulations exist)
[[USLegal:Prescription only|Rx-only]] in US (the veterinary preparations are not for human use)
[[USLegal:Prescription only|Rx-only]] in US since 2020 (OTC 2% formulations withdrawn under CARES Act due to safety concerns)
[[USLegal:Prescription only|Rx-only]] in US. '''Contraindicated in structural heart disease''' — CAST trial (1989) showed increased mortality from class IC agents in patients with prior MI; modern use is limited to structurally normal hearts'"`UNIQ--ref-00001141-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. '''FDA Boxed Warning (2020):''' neuropsychiatric events including agitation, depression, sleep disturbance, and suicidal thoughts; benefit-risk should be reassessed regularly'"`UNIQ--ref-00000160-QINU`"'.
[[USLegal:Prescription only|Rx-only]] in US. '''Federally non-controlled despite being a barbiturate''', a paradoxical situation given that its primary active metabolite phenobarbital is Schedule IV'"`UNIQ--ref-00000019-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. '''Not a controlled substance''', the principal clinical selling point versus psychostimulant ADHD options. Carries the antidepressant-class '''Boxed Warning''' for suicidal ideation in pediatric patients'"`UNIQ--ref-00000016-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries '''Boxed Warning''' for risk of malignancy and serious infection; nephrotoxicity, hypertension, and immunosuppression-associated complications'"`UNIQ--ref-00000A93-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries '''Boxed Warnings''' for hepatotoxicity (especially children <2 with metabolic disorders), teratogenicity, and pancreatitis'"`UNIQ--ref-0000097F-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries '''Boxed Warnings''' for pulmonary toxicity (interstitial pneumonitis, fibrosis), hepatotoxicity, and proarrhythmia'"`UNIQ--ref-00000CB5-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries a '''Boxed Warning''' contraindicating use in children <2 years (lethal dehydration in animal studies)'"`UNIQ--ref-0000119E-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries a '''Boxed Warning''' for '''tardive dyskinesia''' (irreversible movement disorder), driving the 12-week chronic-use limit'"`UNIQ--ref-00000EFB-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries a '''Boxed Warning''' for Clostridioides difficile colitis (one of the most C. difficile-inducing antibiotic classes)'"`UNIQ--ref-00001444-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries a '''Boxed Warning''' for bleeding risk and against aspirin maintenance doses above 100 mg/d (reduces ticagrelor efficacy, per PLATO subgroup analysis)'"`UNIQ--ref-00000C94-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries a '''Boxed Warning''' for bone mineral density loss with prolonged use (≥2 years; partially reversible after discontinuation)'"`UNIQ--ref-00000F22-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries a '''Boxed Warning''' for heart failure (do not initiate in NYHA III/IV; can precipitate or worsen HF in any patient)'"`UNIQ--ref-00000826-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries the '''antidepressant Boxed Warning''' for suicidality in children/adolescents/young adults and the atypical-neuroleptic '''Boxed Warning''' for increased mortality in elderly dementia patients'"`UNIQ--ref-0000154F-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries the FDA '''Boxed Warning for serious skin reactions''' including Stevens-Johnson syndrome and toxic epidermal necrolysis, with the risk concentrated in the first 2-8 weeks of therapy and elevated by rapid titration'"`UNIQ--ref-00000028-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries the NSAID-class '''Boxed Warning''' for cardiovascular thrombotic events and serious GI bleeding'"`UNIQ--ref-000011FB-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults. Not controlled'"`UNIQ--ref-00000025-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-0000001C-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-0000001F-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-0000002E-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries the atypical-neuroleptic '''Boxed Warning''' for increased mortality in elderly patients with dementia-related psychosis'"`UNIQ--ref-00000023-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries the same fluoroquinolone-class '''Boxed Warnings''' as ciprofloxacin/levofloxacin'"`UNIQ--ref-00000D84-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries the same fluoroquinolone-class '''Boxed Warnings''' as ciprofloxacin/levofloxacin'"`UNIQ--ref-000014C5-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Carries the same fluoroquinolone-class '''Boxed Warnings''' as ciprofloxacin: tendinitis/tendon rupture (especially elderly, corticosteroid co-use), peripheral neuropathy, CNS effects, worsening of myasthenia gravis'"`UNIQ--ref-00000CF7-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Caution with QT-prolonging medicines (quinidine itself is class IA antiarrhythmic, and the dose here, though sub-antiarrhythmic, still contributes to QT)'"`UNIQ--ref-00001585-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. NSAID-class '''Boxed Warning''' for CV thrombotic events and GI bleeding; triptans contraindicated in coronary artery disease, peripheral vascular disease, uncontrolled hypertension, and recent ergot or MAOI use'"`UNIQ--ref-000015D3-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. NSAID-class '''Boxed Warning''' for CV thrombotic events and GI bleeding'"`UNIQ--ref-00001270-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Not a controlled substance, distinguishing it from carisoprodol among muscle-spasm options'"`UNIQ--ref-0000001F-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Not a controlled substance, distinguishing it from carisoprodol which is Schedule IV'"`UNIQ--ref-00000019-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Not a controlled substance, distinguishing it from the carisoprodol alternative for muscle spasm'"`UNIQ--ref-0000001C-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Not a controlled substance, like guanfacine and unlike the psychostimulant alternatives for ADHD'"`UNIQ--ref-00000028-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Not a controlled substance, which is a meaningful clinical advantage over benzodiazepine alternatives for chronic anxiety'"`UNIQ--ref-0000001F-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Not a controlled substance, which is a meaningful clinical advantage over the benzodiazepine alternatives for short-term anxiety'"`UNIQ--ref-00000028-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Not a controlled substance, which is a meaningful contrast to the psychostimulant alternatives for ADHD'"`UNIQ--ref-00000022-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Not a controlled substance'"`UNIQ--ref-00000022-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Not a controlled substance'"`UNIQ--ref-00000028-QINU`"'
[[USLegal:Prescription only|Rx-only]] in US. Not a controlled substance'"`UNIQ--ref-0000002B-QINU`"'
[[USLegal:Schedule III|Schedule III controlled substance]] in US (Fiorinal is scheduled federally; Fioricet with acetaminophen is unscheduled federally despite identical butalbital content, a regulatory quirk)
[[USLegal:Schedule III|Schedule III controlled substance]] in US. '''Contraindicated in children <12''' for any indication and in any age post-tonsillectomy/adenoidectomy (FDA 2017 black-box advisory)'"`UNIQ--ref-00001519-QINU`"'
[[USLegal:Schedule II|Schedule II controlled substance]] in US
[[USLegal:Schedule II|Schedule II controlled substance]] in US. Acetaminophen content limited to ≤325 mg per dosage unit (FDA 2014)
[[USLegal:Schedule II|Schedule II controlled substance]] in US; WHO essential medicine'"`UNIQ--ref-00000022-QINU`"'
[[USLegal:Schedule II|Schedule II controlled substance]] in US'"`UNIQ--ref-00000019-QINU`"'
[[USLegal:Schedule II|Schedule II controlled substance]] in US'"`UNIQ--ref-0000001F-QINU`"'
[[USLegal:Schedule IV|Schedule IV controlled substance]] in US (federally scheduled 2014); some states schedule higher'"`UNIQ--ref-0000001F-QINU`"'
[[USLegal:Schedule IV|Schedule IV controlled substance]] in US (tramadol was reclassified from non-controlled to Schedule IV in 2014 after recognition of dependence risk)
[[USLegal:Schedule IV|Schedule IV controlled substance]] in US. Carries the FDA '''Boxed Warning''' for '''complex sleep behaviors''' (sleep-driving, sleep-walking, sleep-eating, other parasomnias) added in 2019'"`UNIQ--ref-0000001C-QINU`"'
[[USLegal:Schedule IV|Schedule IV controlled substance]] in US. Carries the benzodiazepine class '''Boxed Warning''' for risk of fatal respiratory depression, coma, and death when combined with opioids'"`UNIQ--ref-00000025-QINU`"'
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