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Drilldown: Medicines

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Medicines > routes: IV infusion (60 min) every 2 weeks; outpatient or infusion-center setting & pregnancy: Limited data & legal: Rx; REMS-like program for ARIA monitoring

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generic:
None (1)
brand:
Leqembi (1)
classes:
Anti-amyloid beta (Aβ) monoclonal antibody (1) · targets protofibrils (1)
mechanism:
None (1)
uses:
Alzheimer disease (MCI or mild dementia stage); FDA accelerated approval Jan 2023 → traditional approval July 2023 (1)
starting dose:
10 mg/kg IV every 2 weeks (1)
preparations:
200 mg/2 mL, 500 mg/5 mL vials for IV infusion (1)
fda max:
10 mg/kg q2w (1)
routes: (Click arrow to add another value)
onset:
Slowing of cognitive decline over 18 months (modest effect, ~27% relative slowing) (1)
duration:
Ongoing dosing (1)
halflife:
~5-7 days (1)
bioavailability:
100% (IV) (1)
pregnancy: (Click arrow to add another value)
legal: (Click arrow to add another value)

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