Drilldown: Medicines

Bisoprolol (1) · Coffee (1) · Nebivolol (1)

''Coffea arabica'', ''Coffea canephora'' (robusta) (1) · Bystolic (1) · Zebeta (1)

Beta Blocker (2) · Caffeine plant (1) · Cardioselective (β1) (1) · Cardioselective (β1) + vasodilator (1) · Excitantia (1) · Plant Medicine (1) · Xanthine (1)

Caffeine is a non-selective adenosine A1/A2A receptor antagonist; also weak PDE inhibition. Beans contain theobromine (3,7-DMX) and theophylline (1,3-DMX) in smaller amounts. (1) · Highly β1-selective adrenergic antagonist. Greater selectivity than metoprolol or atenolol. (1) · The d-enantiomer is a highly β1-selective antagonist; the l-enantiomer triggers endothelial nitric-oxide–mediated vasodilation. Unique among beta blockers for this NO mechanism. (1)

'"`UNIQ--vote-000000CF-QINU`"', '"`UNIQ--vote-000000D0-QINU`"', '"`UNIQ--vote-000000D1-QINU`"' (1) · '"`UNIQ--vote-0000059D-QINU`"' (1) · '"`UNIQ--vote-00000636-QINU`"', '"`UNIQ--vote-00000637-QINU`"', '"`UNIQ--vote-00000638-QINU`"' (1)

2.5–5 mg daily (HTN); 1.25 mg daily (HFrEF, slow titration) (1) · 5 mg daily (1) · One cup (~80–145 mg caffeine for brewed; 60–100 mg for instant) (1)

2.5, 5, 10, 20 mg tabs (1) · 5, 10 mg tabs (1) · Roasted beans, ground; brewed (drip, French press, espresso, cold brew, percolated) (1)

None (1) · 20 mg/d (1) · 40 mg/d (1)

Oral (3)

None · Hours · 30-60 minutes · 1-2 hours · ~30 min · LDL lowering at 2 weeks, max by 4 weeks · ~1 hour · 15-30 minutes · 15–30 min · 1–2 h · 30–60 min · Antidepressant effect emerges over 1-2 weeks · BP and symptomatic LUTS improvement within 1-2 weeks · BP effect within 1-2 weeks · Clinical improvement within 24-72 hours · Days · Motor improvement over days at therapeutic dose · Over weeks · Postprandial glucose effect within days; HbA1c by 12 weeks · Sleep effect from first dose; antidepressant effect over 1-4 weeks

Other values:

Search

24 h (2) · 3–5 h (subjective) (1)

9–12 h (1) · ~10 h (CYP2D6 extensive metabolizers); up to 31 h (poor metabolizers) (1) · ~5 h (caffeine) (1)

~12% (extensive metabolizers); ~96% (poor metabolizers) (1) · ~90% (low first-pass) (1) · ~99% (caffeine) (1)

Category C (2) · Limit to <200 mg/d (~2 cups brewed) (1)

Rx-only in US (2) · Unrestricted (food) (1)