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Medicines > routes: Subcutaneous (never IV; not for use in insulin pumps) & onset : 1-2 hours or BP effect within 1-2 weeks

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generic:
Insulin glargine (1)
brand:
Lantus, Basaglar, Semglee, Toujeo (U-300) (1)
classes:
[[:Category:Basal_insulins|Basal insulin]] (1) · [[:Category:Insulins|Insulin]] (1) · [[:Category:Long-acting_insulins|Long-acting insulin analog]] (1)
mechanism:
'"`UNIQ--vote-00000237-QINU`"' Binds the same insulin receptor as endogenous insulin with comparable mitogenic-to-metabolic ratio; provides basal hepatic glucose suppression and peripheral glucose uptake without prandial peaks'"`UNIQ--ref-00000238-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000239-QINU`"', '"`UNIQ--vote-0000023A-QINU`"' (1)
starting dose:
~10 units SC at the same time daily, or 0.1-0.2 units/kg/d; titrate by fasting glucose (1)
preparations:
100 U/mL (Lantus, Basaglar, Semglee) vials and pens; 300 U/mL (Toujeo) pens (1)
fda max:
Titrated to glucose; no fixed ceiling (1)
routes: (Click arrow to add another value)
onset: (Click arrow to add another value)
duration:
~24 hours per dose (peakless profile by design) (1)
halflife:
~12 hours apparent (functional duration ~24 hours due to depot release kinetics)'"`UNIQ--ref-0000023B-QINU`"' (1)
bioavailability:
~100% from subcutaneous depot (by definition of the route) (1)
pregnancy:
Insulin is the preferred glucose-lowering therapy in pregnancy; glargine has reassuring observational data, though NPH and detemir remain the traditional choices.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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