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Medicines > routes: vaginal & onset : 15-60 minutes (oral); 1-5 minutes (IV); 4-10 minutes (rectal or intranasal) or Days

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generic:
Clotrimazole (1)
brand:
Lotrimin, Mycelex, Gyne-Lotrimin; OTC widely (1)
classes:
[[:Category:Antifungals|Antifungal (imidazole)]] (1) · [[:Category:Topical_antifungals|Topical antifungal]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000F40-QINU`"', '"`UNIQ--vote-00000F41-QINU`"', '"`UNIQ--vote-00000F42-QINU`"', '"`UNIQ--vote-00000F43-QINU`"', '"`UNIQ--vote-00000F44-QINU`"' (1)
starting dose:
Topical: 1% cream BID × 2-4 weeks; vaginal: 1% or 2% cream nightly × 7 days, or 100/200/500 mg vaginal tablet single or 3-day regimens; troche: 10 mg PO five times daily × 2 weeks for thrush (1)
preparations:
1% topical cream, lotion, solution; 1%, 2% vaginal cream; 100, 200, 500 mg vaginal tablets; 10 mg oral troches; combination with betamethasone (Lotrisone, Rx) (1)
fda max:
Topical: BID; troche: 5×/day (1)
routes: (Click arrow to add another value)
onset: (Click arrow to add another value)
duration:
Hours per application (1)
halflife:
Not meaningfully described (minimal systemic absorption from topical use)'"`UNIQ--ref-00000F45-QINU`"' (1)
bioavailability:
Topical: minimal systemic; troche: ~3% systemic'"`UNIQ--ref-00000F46-QINU`"' (1)
pregnancy:
Topical and vaginal generally considered safe; widely used.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC (lower strengths) and [[USLegal:Prescription only|Rx-only]] (combination with betamethasone) in US (1)

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