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Medicines (732)

Medicines > routes: Oral

& onset

: Anticonvulsant effect emerges with slow titration over weeks; tremor effect over weeks

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Primidone (1)

Mysoline (1)

[[:Category:Anticonvulsants|Anticonvulsant]] (1) · [[:Category:Barbiturates|Barbiturate (parent compound)]] (1) · [[:Category:Tremor medicines|Tremor medicine]] (1)

'"`UNIQ--vote-00000013-QINU`"' Strong CYP3A4 induction via the phenobarbital metabolite produces many interactions (reduces oral contraceptives, warfarin, many psychotropics). Essential-tremor efficacy is the unique pharmacological selling point'"`UNIQ--ref-00000014-QINU`"'. (1)

'"`UNIQ--vote-00000015-QINU`"', '"`UNIQ--vote-00000016-QINU`"' (1)

Seizures: 100-125 mg PO at bedtime x 3 days, then BID, then TID, escalating to 750-1500 mg/day. Essential tremor: 25-50 mg PO at bedtime, titrate slowly to 250-750 mg/day (1)

Tablets 50, 250 mg (1)

2 g/day (seizures); typically much lower for essential tremor (1)

BID-TID dosing (1)

Primidone 5-15 hours; '''phenobarbital active metabolite 50-150 hours'''; PEMA (phenylethylmalonamide) active metabolite 16 hours'"`UNIQ--ref-00000017-QINU`"' (1)

~90% (oral)'"`UNIQ--ref-00000018-QINU`"' (1)

Substantial teratogenic signal (barbiturate class effects including neonatal withdrawal and hemorrhagic disease of newborn).<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1)

[[USLegal:Prescription only|Rx-only]] in US. '''Federally non-controlled despite being a barbiturate''', a paradoxical situation given that its primary active metabolite phenobarbital is Schedule IV'"`UNIQ--ref-00000019-QINU`"' (1)

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P

Primidone

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