Drilldown: Medicines

None (2) · Sertraline (1)

Ajovy (1) · Emgality (1) · Zoloft (1)

Anti-CGRP ligand monoclonal antibody (2) · Antidepressant (1) · Anxiolytic (1) · SSRI (1)

Humanized IgG2 monoclonal antibody binding both isoforms of CGRP peptide (1) · Humanized IgG4 monoclonal antibody binding CGRP peptide; prevents CGRP from activating its receptor (1) · TrkB/BDNF'"`UNIQ--ref-00000084-QINU`"' '"`UNIQ--vote-00000085-QINU`"' (1)

None (1) · Preventive treatment of migraine in adults (episodic and chronic) (1) · Preventive treatment of migraine in adults; episodic cluster headache (1)

225 mg SC monthly, or 675 mg SC every 3 months (quarterly) (1) · 25 mg (1) · Migraine: 240 mg SC loading dose, then 120 mg SC monthly. Cluster: 300 mg SC at onset of cluster period, then monthly during cluster. (1)

120 mg/mL prefilled syringe or autoinjector (1) · 225 mg/1.5 mL prefilled syringe or autoinjector (1) · 25 mg, 50 mg, 100 mg tablets; oral concentrate 20 mg/mL (1)

200 mg/d (1) · 240 mg loading + 120 mg/month for migraine; 300 mg/month for cluster (1) · 675 mg/quarter (1)

Oral (1) · Subcutaneous (2)

None · Hours · 30-60 minutes · 1-2 hours · ~30 min · LDL lowering at 2 weeks, max by 4 weeks · ~1 hour · 15-30 minutes · 15–30 min · 1–2 h · 30–60 min · Antidepressant effect emerges over 1-2 weeks · BP and symptomatic LUTS improvement within 1-2 weeks · BP effect within 1-2 weeks · Clinical improvement within 24-72 hours · Days · Motor improvement over days at therapeutic dose · Over weeks · Postprandial glucose effect within days; HbA1c by 12 weeks · Sleep effect from first dose; antidepressant effect over 1-4 weeks

Other values:

Search

Long (1) · Monthly dosing (1) · Monthly or quarterly dosing (1)

~26 h (sertraline; range 13-45 h, longer in females); ~62-104 h (N-desmethylsertraline, weakly active) (1) · ~27 days (1) · ~31 days (1)

Absolute bioavailability not precisely characterized; food modestly increases exposure (1) · Not formally established (1) · Not formally established (high SC) (1)

Category C'"`UNIQ--ref-0000008F-QINU`"' (1) · Limited data; avoid (2)

Rx (2) · Rx-only in US (1)