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Medicines > routes: subcutaneous & onset : Over weeks or Topical: irritation within days; acne improvement 6-12 weeks; oral APL response within days

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generic:
None (2)
brand:
Ajovy (1) · Emgality (1)
classes:
Anti-CGRP ligand monoclonal antibody (2)
mechanism:
Humanized IgG2 monoclonal antibody binding both isoforms of CGRP peptide (1) · Humanized IgG4 monoclonal antibody binding CGRP peptide; prevents CGRP from activating its receptor (1)
uses:
Preventive treatment of migraine in adults (episodic and chronic) (1) · Preventive treatment of migraine in adults; episodic cluster headache (1)
starting dose:
225 mg SC monthly, or 675 mg SC every 3 months (quarterly) (1) · Migraine: 240 mg SC loading dose, then 120 mg SC monthly. Cluster: 300 mg SC at onset of cluster period, then monthly during cluster. (1)
preparations:
120 mg/mL prefilled syringe or autoinjector (1) · 225 mg/1.5 mL prefilled syringe or autoinjector (1)
fda max:
240 mg loading + 120 mg/month for migraine; 300 mg/month for cluster (1) · 675 mg/quarter (1)
routes: (Click arrow to add another value)
onset: (Click arrow to add another value)
duration:
Monthly dosing (1) · Monthly or quarterly dosing (1)
halflife:
~27 days (1) · ~31 days (1)
bioavailability:
Not formally established (1) · Not formally established (high SC) (1)
pregnancy:
Limited data; avoid (2)
legal:
Rx (2)

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