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Medicines (732)

Medicines > routes

: Oral (IV form withdrawn US 2009 due to fatal toxicity reports)

or topical ophthalmic

& onset: Anti-inflammatory effect within 24 hours of gout flare onset; loses effectiveness if delayed

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Colcrys, Mitigare, Gloperba, Lodoco (low-dose cardiovascular) (1)

[[:Category:Anti-inflammatories|Anti-inflammatory]] (1) · [[:Category:Antigout_agents|Antigout agent]] (1) · [[:Category:Microtubule_inhibitors|Microtubule inhibitor]] (1)

None (1)

'"`UNIQ--vote-00000C6D-QINU`"', '"`UNIQ--vote-00000C6E-QINU`"', '"`UNIQ--vote-00000C6F-QINU`"', '"`UNIQ--vote-00000C70-QINU`"', '"`UNIQ--vote-00000C71-QINU`"' (1)

Acute gout: 1.2 mg PO at first symptom, then 0.6 mg 1 hour later (total 1.8 mg in 1 hour, the FDA-revised regimen); prophylaxis 0.6 mg PO daily or BID; FMF 1-2 mg/d; pericarditis 0.5-0.6 mg BID for 3 months; Lodoco 0.5 mg PO daily for CV risk reduction (1)

0.6 mg tablets; 0.6 mg/5 mL solution; 0.5 mg tablets (Lodoco) (1)

1.8 mg in any 1-hour period (acute gout); 1.2 mg/d (prophylaxis with renal/hepatic impairment); much lower with strong CYP3A4 or P-gp inhibitors (1)

Hours per dose (1)

~27-31 hours; markedly prolonged in renal/hepatic impairment and with CYP3A4 or P-gp inhibitors'"`UNIQ--ref-00000C72-QINU`"' (1)

~45% (oral)'"`UNIQ--ref-00000C73-QINU`"' (1)

Used in FMF in pregnancy; otherwise weigh against alternatives.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1)

[[USLegal:Prescription only|Rx-only]] in US (1)

Showing below up to 1 result in range #1 to #1.

C

Colchicine

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